P49009
Gene name |
HEXA (BEX-1, HEX-A1) |
Protein name |
Beta-hexosaminidase subunit alpha |
Names |
Beta-GlcNAcase subunit alpha, Beta-N-acetylhexosaminidase subunit alpha, N-acetyl-beta-glucosaminidase subunit alpha |
Species |
Entamoeba histolytica |
KEGG Pathway |
|
EC number |
3.2.1.52: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P49009
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P49009-F1 | Predicted | AlphaFoldDB |
No variants for P49009
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P49009 | |||||
No associated diseases with P49009
8 regional properties for P49009
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | SEC-C motif | 883 - 900 | IPR004027 |
| domain | SecA DEAD-like, N-terminal | 8 - 391 | IPR011115 |
| domain | SecA Wing/Scaffold | 613 - 824 | IPR011116 |
| domain | SecA, preprotein cross-linking domain | 230 - 347 | IPR011130 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 91 - 249 | IPR014001 |
| domain | SecA motor DEAD | 5 - 615 | IPR014018 |
| conserved_site | SecA conserved site | 490 - 505 | IPR020937 |
| domain | SecA, C-terminal helicase domain | 409 - 585 | IPR044722 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.2.1.52 | Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-N-acetylhexosaminidase activity | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. |
| N-acetyl-beta-D-galactosaminidase activity | Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl- |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLFIFIVFIS | SVFAGNGLNV | QNQLLLMPYP | SSVSFQWKSP | LAIALTSSIQ | LNVKSTCNTD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CMNFLKSNFN | HTISFPLQQQ | TGLQDFKVSL | FKEIDLPRIT | PSVSSVITDV | VVELSSSNPM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKLQIGFDES | YILEVTTNSI | SIKAVTVYGA | RHAFETLLQL | IRISSNKFVI | SQLPIKISDA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PRFKWRGLMV | DPSRNPLSPL | MFKRIIDTLA | SVKANVLHIH | LSDAQTFVFE | SKKYPLLHQK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GMYDESFVLT | QSFLRELAQY | GANRGVIVYG | EIDTPAHTAS | WNLGYPGVVA | NCWDYIVSTS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MRYGENVLSL | NPANPNTFPI | IDALMKELSD | TFGTDYVHVG | GDEVWTSGWS | KSKEYSDIQK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FMKSKGLNSL | TELEGYFNKY | AQEQVIHNGK | HPVVWEEVFK | KGNADKNTII | QVWDDIRLLQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QVVNSGYKAI | FSAGFYLDKQ | MPLCNSYDSS | TCVNTHSMWV | WTNRDMYDND | PVKSLSSSEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ENVLGGEGCS | WGESTDEQNF | FDRVFQRYSA | IAERLWSKES | VVDKESHEVR | ANYLRCLDVR |
| 550 | 560 | ||||
| RDIMKGTGPL | YHSFCQLPKK | EKSN |