P48996

PR
Gene name
dpy-27 (R13G10.1)
Protein name
Chromosome condensation protein dpy-27
Names
Protein dumpy-27
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_R13G10.1
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

472-565 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P48996

Entry ID Method Resolution Chain Position Source
AF-P48996-F1 Predicted AlphaFoldDB

No variants for P48996

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P48996

No associated diseases with P48996

3 regional properties for P48996

Type Name Position InterPro Accession
domain RecF/RecN/SMC, N-terminal 93 - 521 IPR003395-1
domain RecF/RecN/SMC, N-terminal 835 - 1327 IPR003395-2
domain SMCs flexible hinge 621 - 737 IPR010935

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
  • In interphase cells, diffusely distributed in nuclei before the onset of dosage compensation (PubMed:19119011)
  • Associates with chromatin after the 30-cell stage when dosage compensation is initiated (PubMed:19119011, PubMed:23028348, PubMed:7954812)
  • Specifically localizes to the X chromosomes of hermaphrodite (XX) embryos, but remains diffusely distributed throughout the nuclei of male (XO) embryos (PubMed:23028348, PubMed:7954812)
  • dpy-26 is required for its X chromosome specific association (PubMed:8939870)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
dosage compensation complex A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes.
nuclear chromosome A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
X chromosome The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

3 GO annotations of biological process

Name Definition
dosage compensation by hypoactivation of X chromosome Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans.
mitotic chromosome condensation The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQPFKRRALT SDDDRPYADT DSMPEVDLDV DRRRQYMEQL NIFDDVSSGA YMLELEAAEN
70 80 90 100 110 120
GVKYDEKEDL LNVQIPPKYE DQISDPDGNR MIILNIYVEN FKSYAGKHIL GPFHKNLTMI
130 140 150 160 170 180
LGPNGSGKSN VIDALLFVFG FKAGKIRTKK LSALINSGGN YESCSVTIMF QMVKDMPVEN
190 200 210 220 230 240
YDKYEVLTDN CVCITRTINR ENNSKYRIDD KDASQKDVQE LLLRAGIDMT HNRFLILQGE
250 260 270 280 290 300
VEAIALMKPT SKNPNEEGML EYIEDIVGTN RFVAPISKLM HRVSLLEHKS SQYGASVRRH
310 320 330 340 350 360
EGHLKVFEKA MVIGMAYLNT FNNLNYLRGI RVKHNLCRYA ETMRDAKMSL VTRTGELEEN
370 380 390 400 410 420
KDIMLEAKDE VRKKETHERS LNSIVTELEN KRIDWQSKKN DWHARDAKRK QGLKSCTQDL
430 440 450 460 470 480
GKLMKERDEA RREKFEIETA PENARISKQN MQLEWDQLKE QENVCQRTAT ENLIKYDQKS
490 500 510 520 530 540
SADRAKHDDL EKKLSDELLQ SMRAKAELDV SESELKDMTI MMEQGQKRVD ELKGTLQTMM
550 560 570 580 590 600
AENIRDNTEL NAVTTELQDR KLKFDKAVEK LPHLKSTEQL LRSKKYELDQ EVIEASNTQE
610 620 630 640 650 660
VTYRHQATAK LHELKEAGLF PGFKGRLGDL ASIPIKFDTA ISTVFFAQLD YHVVQTSDEC
670 680 690 700 710 720
RIGIGFCHEY KLPRTTFVFL DHLKDTDTSG MDSTMKFPAE RLFDKIHCVN PEIRREFYFL
730 740 750 760 770 780
IHDILVVDSL EEATRIDKKY PGRHRYCTLN GSILNRSGAL TGGGKPTTGR IRNDNNPNMS
790 800 810 820 830 840
GVKKVDLSKL RAAQEKHNHA LEAHLKLQLK QEEIRADNGP IIKQLEIRKR ELIMSTKEQK
850 860 870 880 890 900
TRIAELKSSI AAHERRMVNY REVTVEDLDE KRAQIADLKR QVEESQKSSA KIKQQIEQYK
910 920 930 940 950 960
RKMDRMFMEL VQKNKDSIEQ AKDRMGQLEQ DIARQTAIIE NNPSHLEQAE KKLSELEHMC
970 980 990 1000 1010 1020
LEKRSEADAL AQLEVGEDVK GIDIINAQLQ TSTASIDAQR ARYTEAVAAR READAAYQTT
1030 1040 1050 1060 1070 1080
VDNYNMVKQT YDELMRIIDD LENKTMADNA ELDIIESAWM QPEKLYPPGK FVRYNDPDIA
1090 1100 1110 1120 1130 1140
AKMTDGHVVL PYECISMIEP HREAYEEHEA RMLEDDVFED TANKICKLEK DVDKFRREFD
1150 1160 1170 1180 1190 1200
NKGVRDYAMI VSLLMNEVTS AKKFSDKLKA HREKLNELRM ARFNEFSEAL AFLGTTTQML
1210 1220 1230 1240 1250 1260
YQLITNGGDA SLKFVEEGKS TDPFDGGIKF SVRPAKKSWK LIENLSGGEK TLASLCFVFA
1270 1280 1290 1300 1310 1320
MHHYRPTPLY VMDEIDAALD LNNVSLIANY IKHSERTRNA QFIIISLRNQ MFEVGNRLLG
1330 1340 1350 1360 1370 1380
IYKIDGKTYN IMVDPIAVEI KNRPILKIFE EEIKRREKLR RAEIEPEIDL SNGLSNVVIA
1390 1400 1410 1420 1430 1440
PKRKQRRLEM LKLSDFGLDD DSDLPEFNRF PPATRRELSV EDSDEDDEPV RRRPRRQVEE
1450 1460
EDEEDELIEE ATPSPPPIVV QRRVRRSRH