P48826

PR
Gene name
gsdA (g6pdh)
Protein name
Glucose-6-phosphate 1-dehydrogenase
Names
G6PD
Species
Aspergillus niger
KEGG Pathway
EC number
1.1.1.49: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P48826

Entry ID Method Resolution Chain Position Source
AF-P48826-F1 Predicted AlphaFoldDB

No variants for P48826

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P48826

No associated diseases with P48826

19 regional properties for P48826

Type Name Position InterPro Accession
repeat LDLR class B repeat 359 - 399 IPR000033-1
repeat LDLR class B repeat 697 - 736 IPR000033-2
repeat LDLR class B repeat 738 - 780 IPR000033-3
repeat LDLR class B repeat 781 - 819 IPR000033-4
domain Protein kinase domain 1945 - 2222 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 1948 - 2215 IPR001245
conserved_site Tyrosine-protein kinase, receptor class II, conserved site 2108 - 2116 IPR002011
domain Fibronectin type III 99 - 196 IPR003961-1
domain Fibronectin type III 195 - 285 IPR003961-2
domain Fibronectin type III 557 - 671 IPR003961-3
domain Fibronectin type III 948 - 1028 IPR003961-4
domain Fibronectin type III 1041 - 1150 IPR003961-5
domain Fibronectin type III 1469 - 1539 IPR003961-6
domain Fibronectin type III 1557 - 1656 IPR003961-7
domain Fibronectin type III 1658 - 1751 IPR003961-8
domain Fibronectin type III 1753 - 1842 IPR003961-9
active_site Tyrosine-protein kinase, active site 2075 - 2087 IPR008266
binding_site Protein kinase, ATP binding site 1951 - 1980 IPR017441
domain Tyrosine-protein kinase, catalytic domain 1945 - 2215 IPR020635

Functions

Description
EC Number 1.1.1.49 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
glucose-6-phosphate dehydrogenase activity Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

2 GO annotations of biological process

Name Definition
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
pentose-phosphate shunt The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASTIARTEE RQNAGTMELK DDTVIIVLGA SGDLAKKKTF PALFGLYRNK FLPKGIKIVG
70 80 90 100 110 120
YARTNMDHEE YLRRVRSYIK TPTKEIEEQL DSFCQFCTYI SGQYDKDDSF INLNKHLEEI
130 140 150 160 170 180
EKGQKEQNRI YYMALPPSVF TTVSDQLKRN CYPKNGVARI IVEKPFGKDL QSSRDLQKAL
190 200 210 220 230 240
EPNWKEEEIF RIDHYLGKEM VKNILIMRFG NEFFNATWNR HHIDNVQITF KEPFGTEGRG
250 260 270 280 290 300
GYFDEFGIIR DVMQNHLLQV LTLLAMERPI SFSAEDIRDE KVRVLRAMDA IEPKNVIIGQ
310 320 330 340 350 360
YGKSLDGSKP AYKEDETVPQ DSRCPTFCAM VAYIKNERWD GVPFIMKAGK ALNEQKTEIR
370 380 390 400 410 420
IQFRDVTSGI FKDIPRNELV IRVQPNESVY IKMNSKLPGL SMQTVVTELD LTYRRRFSDL
430 440 450 460 470 480
KIPEAYESLI LDALKGDHSN FVRDDELDAS WRIFTPLLHY LDDNKEIIPM EYPYGSRGPA
490 500
VLDDFTASFG YKFSDAAGYQ WPLTSTPNRL