P48760
PR
Gene name |
Fpgs |
Protein name |
Folylpolyglutamate synthase, mitochondrial |
Names |
Folylpoly-gamma-glutamate synthetase, FPGS, Tetrahydrofolylpolyglutamate synthase, Tetrahydrofolate synthase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14287 |
EC number |
6.3.2.17: Acid--amino-acid ligases (peptide synthases) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P48760
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P48760-F1 | Predicted | AlphaFoldDB |
32 variants for P48760
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388547568 | 28 | A>V | No | EVA | |
| rs3391485355 | 43 | M>R | No | EVA | |
| rs3388546475 | 75 | Q>* | No | EVA | |
| rs3391421983 | 128 | F>L | No | EVA | |
| rs3391432327 | 128 | F>V | No | EVA | |
| rs3388544261 | 178 | F>Y | No | EVA | |
| rs3388547237 | 186 | F>Y | No | EVA | |
| rs3388545167 | 191 | Q>* | No | EVA | |
| rs3388545164 | 192 | E>D | No | EVA | |
| rs3388545240 | 193 | K>N | No | EVA | |
| rs3391432364 | 262 | P>L | No | EVA | |
| rs3388541159 | 284 | E>K | No | EVA | |
| rs3388544180 | 311 | Q>H | No | EVA | |
| rs27208028 | 313 | A>T | No | EVA | |
| rs3388547257 | 327 | E>D | No | EVA | |
| rs3388544121 | 340 | P>S | No | EVA | |
| rs3388546667 | 381 | T>S | No | EVA | |
| rs27208033 | 409 | H>Y | No | EVA | |
| rs3388545150 | 429 | Q>H | No | EVA | |
| rs3388548607 | 433 | F>L | No | EVA | |
| rs3388549195 | 442 | V>E | No | EVA | |
| rs3388547269 | 451 | A>E | No | EVA | |
| rs3388545425 | 473 | H>Y | No | EVA | |
| rs3388544135 | 477 | L>M | No | EVA | |
| rs246461856 | 491 | G>R | No | EVA | |
| rs246461856 | 491 | G>S | No | EVA | |
| rs3388549153 | 497 | P>R | No | EVA | |
| rs3388541162 | 500 | L>Q | No | EVA | |
| rs3388538737 | 511 | R>K | No | EVA | |
| rs3388538659 | 524 | L>* | No | EVA | |
| rs3388548550 | 536 | Q>* | No | EVA | |
| rs3388543511 | 561 | A>D | No | EVA |
No associated diseases with P48760
10 regional properties for P48760
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Actinin-type actin-binding domain, conserved site | 211 - 235 | IPR001589-1 |
| conserved_site | Actinin-type actin-binding domain, conserved site | 399 - 408 | IPR001589-2 |
| conserved_site | Actinin-type actin-binding domain, conserved site | 478 - 502 | IPR001589-3 |
| domain | Calponin homology domain | 123 - 239 | IPR001715-1 |
| domain | Calponin homology domain | 267 - 378 | IPR001715-2 |
| domain | Calponin homology domain | 397 - 506 | IPR001715-3 |
| domain | Calponin homology domain | 518 - 627 | IPR001715-4 |
| domain | EF-hand domain | 12 - 87 | IPR002048 |
| binding_site | EF-Hand 1, calcium-binding site | 25 - 37 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 65 - 77 | IPR018247-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.2.17 | Acid--amino-acid ligases (peptide synthases) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| tetrahydrofolylpolyglutamate synthase activity | Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| animal organ regeneration | The regrowth of a lost or destroyed animal organ. |
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| folic acid-containing compound biosynthetic process | The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. |
| folic acid-containing compound metabolic process | The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. |
| glutamate metabolic process | The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. |
| liver development | The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. |
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| tetrahydrofolylpolyglutamate biosynthetic process | The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05932 | FPGS | Folylpolyglutamate synthase, mitochondrial | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSWARSRLCS | TLSLAAVSAR | GATTEGAARR | GMSAWPAPQE | PGMEYQDAVR | TLNTLQTNAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YLEQVKRQRS | DPQAQLEAME | MYLARSGLQV | EDLNRLNIIH | VTGTKGKGST | CAFTERILRN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YGLKTGFFSS | PHMVQVRERI | RINGKPISPE | LFTKHFWCLY | NQLEEFKDDS | HVSMPSYFRF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LTLMAFHVFL | QEKVDLAVVE | VGIGGAFDCT | NIIRKPVVCG | VSSLGIDHTS | LLGDTVEKIA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WQKGGIFKPG | VPAFTVVQPE | GPLAVLRDRA | QQIGCPLYLC | PPLEALEEVG | LPLSLGLEGA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HQRSNAALAL | QLAHCWLERQ | DHQDIQELKV | SRPSIRWQLP | LAPVFRPTPH | MRRGLRDTVW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PGRTQILQRG | PLTWYLDGAH | TTSSVQACVH | WYRQSLERSK | RTDGGSEVHI | LLFNSTGDRD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SAALLKLLQP | CQFDYAVFCP | NVTEVSSIGN | ADQQNFTVTL | DQVLLRCLQH | QQHWNGLAEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QASSNLWSSC | GPDPAGPGSL | LLAPHPPQPT | RTSSLVFSCI | SHALLWISQG | RDPIFQPQSL |
| 550 | 560 | 570 | 580 | ||
| PRNLLNHPTA | NSGASILREA | AAIHVLVTGS | LHLVGGVLKL | LDPSMSQ |