P48515

PR
Gene name
infB (TTHA0699)
Protein name
Translation initiation factor IF-2
Names
Species
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
KEGG Pathway
ttj:TTHA0699
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P48515

Entry ID Method Resolution Chain Position Source
3J4J EM 1150 A A 1-569 PDB
4B3X X-ray 195 A A 1-363 PDB
4B43 X-ray 194 A A 1-363 PDB
4B44 X-ray 270 A A 1-363 PDB
4B47 X-ray 230 A A 1-363 PDB
4B48 X-ray 280 A A 1-363 PDB
4KJZ X-ray 280 A A/B/C/D 2-474 PDB
5LMV EM 490 A a 1-571 PDB
AF-P48515-F1 Predicted AlphaFoldDB

No variants for P48515

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P48515

No associated diseases with P48515

5 regional properties for P48515

Type Name Position InterPro Accession
domain Translational (tr)-type GTP-binding domain 71 - 239 IPR000795
domain Small GTP-binding protein domain 74 - 230 IPR005225
domain Translation initiation factor IF-2, N-terminal 1 - 48 IPR006847
domain Translation initiation factor IF- 2, domain 3 348 - 462 IPR023115
domain Translation initiation factor IF-2, domain II 247 - 335 IPR044145

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKVRIYQLA KELGMETQEL LELLDQMGVA YKSHASTLEE KDAEAVRELV KEQRGLQEKL
70 80 90 100 110 120
AEEERRKSLP RRPPVVVIMG HVDHGKTTLL DYLRKSRIAE KEAGGITQHV GAFEVKTPQG
130 140 150 160 170 180
TVVFIDTPGH EAFTTIRQRG AKVADIAVIV IAADDGIMPQ TEEAIAHAKA AGAKLIFAIN
190 200 210 220 230 240
KIDLPQADPE KVKRQLMERG FVPEEYGGDA IVIPISAKTG QGVQDLLEMI LLLAELEDYR
250 260 270 280 290 300
ADPNAEPRGV ILESKLDKQA GIIANMLVQE GTFRVGDYVV AGEAYGRIRA MMDADGNQRK
310 320 330 340 350 360
EAGPGSAVQV LGFQELPHAG DVVEWVPDLE AAKEIAEERK EERKAREEEE KARRPRTMAE
370 380 390 400 410 420
LLRAMQEEGR KELNLILRAD TQGSLEAIQH ILARESTEDV KINILLAQVG APTESDVLLA
430 440 450 460 470 480
QTANAAILAF GVNPPGSVKK KAEEKGVLLK TFRIIYDLVD EVRNMVKGQR EPQYKEEVLG
490 500 510 520 530 540
QAEVRAIFRL PTGKQVAGCM VTQGRIPRNA EVRVLRDGQV IWQGRIASLK RFKEDVREVA
550 560 570
QGYECGIGLD GFDDFREGDV IEAFQMVEVP A