P48372

PR
Gene name
gyrA
Protein name
DNA gyrase subunit A
Names
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA3168
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

868-923 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P48372

Entry ID Method Resolution Chain Position Source
AF-P48372-F1 Predicted AlphaFoldDB

No variants for P48372

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P48372

No associated diseases with P48372

7 regional properties for P48372

Type Name Position InterPro Accession
domain DNA topoisomerase, type IIA, domain A 11 - 510 IPR002205
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 539 - 586 IPR006691-1
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 591 - 638 IPR006691-2
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 689 - 732 IPR006691-3
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 737 - 781 IPR006691-4
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 788 - 833 IPR006691-5
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 837 - 883 IPR006691-6

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGELAKEILP VNIEDELKQS YLDYAMSVIV GRALPDARDG LKPVHRRVLY AMSELGNDWN
70 80 90 100 110 120
KPYKKSARVV GDVIGKYHPH GDTAVYDTIV RMAQPFSLRY MLVDGQGNFG SVDGDNAAAM
130 140 150 160 170 180
RYTEVRMAKL AHELLADLEK ETVDWVPNYD GTEQIPAVMP TKIPNLLVNG SSGIAVGMAT
190 200 210 220 230 240
NIPPHNLGEV IDGCLALMDN PDLTVDELMQ YIPGPDFPTA GIINGRAGII EAYRTGRGRI
250 260 270 280 290 300
YIRARAVVEE MEKGGGREQI IITELPYQLN KARLIEKIAE LVKEKKIEGI SELRDESDKD
310 320 330 340 350 360
GMRVVIELRR GEVGEVVLNN LYAQTQLQSV FGINVVALVD GQPRTLNLKD MLEVFVRHRR
370 380 390 400 410 420
EVVTRRTVYE LRKARERGHI LEGQAVALSN IDPVIELIKS SPTPAEAKER LIATAWESSA
430 440 450 460 470 480
VEAMVERAGA DACRPEDLDP QYGLRDGKYY LSPEQAQAIL ELRLHRLTGL EHEKLLSEYQ
490 500 510 520 530 540
EILNLIGELI RILTNPARLM EVIREELEAV KAEFGDARRT EIVASQVDLT IADLITEEDR
550 560 570 580 590 600
VVTISHGGYA KSQPLAAYQA QRRGGKGKSA TGMKDEDYIE HLLVANSHAT LLLFSSKGKV
610 620 630 640 650 660
YWLRTFEIPE ASRTARGRPL VNLLPLDEGE RITAMLQIDL EALQQNGGAD DDLDEAEGAV
670 680 690 700 710 720
LEGEVVEAAE VEEVEGETAE LVAEPTGAYI FMATAFGTVK KTPLVQFSRP RSSGLIALKL
730 740 750 760 770 780
EEGDTLIAAA ITDGAKEVML FSSAGKVIRF AESVVRIMGR NARGVRGMRL GKGQQLISML
790 800 810 820 830 840
IPESGAQILT ASERGFGKRT PLSKFPRRGR GGQGVIAMVT NERNGALIAA VQVQEGEEIM
850 860 870 880 890 900
LISDQGTLVR TRVDEVSLSG RNTQGVTLIK LASDEVLVGL ERVQEPSGGD DEDLPEGEEA
910 920
AESLGESAES ESEPAAEAEG NEE