P48369

PR
Gene name
gyrA
Protein name
DNA gyrase subunit A
Names
Species
Aeromonas salmonicida
KEGG Pathway
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

867-922 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P48369

Entry ID Method Resolution Chain Position Source
AF-P48369-F1 Predicted AlphaFoldDB

No variants for P48369

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P48369

No associated diseases with P48369

7 regional properties for P48369

Type Name Position InterPro Accession
domain DNA topoisomerase, type IIA, domain A 25 - 514 IPR002205
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 544 - 583 IPR006691-1
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 594 - 641 IPR006691-2
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 653 - 696 IPR006691-3
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 700 - 749 IPR006691-4
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 813 - 856 IPR006691-5
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 864 - 910 IPR006691-6

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDLAREITP INIEEELKSS YLDYAMSVIV GRALPDVRDG LKPVHRRVLF AMNELGNDWN
70 80 90 100 110 120
KPYKKSARVV GDVIGKYHPH GDSAVYDTIV RLAQDFSMRY MLVDGQGNFG SVDGDSAAAM
130 140 150 160 170 180
RYTEVRMARI SHELLADLDK ETVDWVPNYD GTEMIPAVMP TKVPNLLVNG SSGIAVGMAW
190 200 210 220 230 240
NIPPHNLTEI VNGCLALIEN GNLTIDELMT YITGPDFPTG AIINGRAGIV QAYRTGRGSV
250 260 270 280 290 300
YVRAKAEVEV DDKTSRETII IVHELPYQVN KARLIEKIAE LVKEKKVEGI SALRDESDKD
310 320 330 340 350 360
ACRIVIEIKR GESGEIVLNN LYKHTQLQTT FGINMVALDN NQPKVMNLKD ILDAFLLHRR
370 380 390 400 410 420
EVVTRRTVFE LRKARDRAHI LEGLAVALAN IDPIIELIRH SDTPADAKAK LVARGWELGN
430 440 450 460 470 480
VAAMLEKAGD DAARPEWLEP EFGIREGQYF LTEQQAQAIL DLRLHKLTGL EHGKILEEYQ
490 500 510 520 530 540
SLLDLIAELL FILASPERLM EVIRDELLAV REQYGDERPP EISASSAEIN IEDLITPEDV
550 560 570 580 590 600
VVTLSHQGYV KYQPITDYEA QRRGGRGKSA TRIKEENFVE RLLVANTHDT ILCFSTRGKV
610 620 630 640 650 660
YWLKVYQLPE ASRGARGRPI INLLPLEEGE RITAILPVKE YADDKYVFFA TADGTVKKTS
670 680 690 700 710 720
LSAFSRPLSS GIRAINLKEG DELIGVDITD GSNEIMLFSD AGKVVRFNEG SAAPMQPMLM
730 740 750 760 770 780
SSDDVDGDDE SVIDAGNDDD GSDNGEGSES TESKGTFKGV RPMGRTAGGV RGIRLLNGDK
790 800 810 820 830 840
VVSLIVPRGE GAILTATENG YGKGTALTEY PTKSRGTQGV RSIKVDEDGK VSIDQVDDTD
850 860 870 880 890 900
QIMLITNGGT LVRTRVSEVS IIGRNTGGVR LIRTGEDETV VGLQRIAESY EEENDVMAID
910 920
GEVSEGTDTA PDAGSAAADP EE