P48360

PR
Gene name
ARH1
Protein name
Probable NADPH:adrenodoxin oxidoreductase, mitochondrial
Names
LEP-R, B219, OB receptor, OB-R, LEP-R, HuB219, OB receptor, OB-R, AR, Adrenodoxin reductase, Ferredoxin--NADP(+) reductase, Ferredoxin reductase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR376W
EC number
1.18.1.6: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P48360

Entry ID Method Resolution Chain Position Source
AF-P48360-F1 Predicted AlphaFoldDB

11 variants for P48360

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-1227331 173 G>D No SGRP
s04-1227769 319 R>K No SGRP
s04-1227791 326 N>K No SGRP
s04-1227814 334 R>Q No SGRP
s04-1227982 390 R>P No SGRP
s04-1228048 412 S>N No SGRP
s04-1228208 465 K>N No SGRP
s04-1228276 488 N>S No SGRP
s04-1228278 489 G>S No SGRP
s04-1228282 490 V>A No SGRP
s04-1228281 490 V>I No SGRP

No associated diseases with P48360

No regional properties for P48360

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P48360

Functions

Description
EC Number 1.18.1.6 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
NADPH-adrenodoxin reductase activity Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

2 GO annotations of biological process

Name Definition
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFVQIRHIS SQINRKTVSI VGSGPSGFYT AYHLLKKSPI PLNVTIWEKL PVPFGLSRYG
70 80 90 100 110 120
VAPDHPEVKN CEETFTTCAE EFSSPTNQKH KFSFVGGITI GKEILLKELL DNQDAVILSY
130 140 150 160 170 180
GCTGDRKLNI PGELGTKGVF SSREFVNWYN GHPDFAKDKR FTDFDWSKVS KVGIIGNGNV
190 200 210 220 230 240
ALDITRVLIS NQIDEIWENT DISSLALNLL RRAPVKDVKL IARRDFVHSK FTNKELRELW
250 260 270 280 290 300
ELEKYGIRGR IDPKFFQKEM FDPSKYDRAF NRRVEMCSEY LKPFNERSKK NYKKAPPPSS
310 320 330 340 350 360
GYDKFWELDY LKTPLKINRD DFGAINSLSL CNNRLNEDNS LQPLKDVNNI MTYKVDLLIT
370 380 390 400 410 420
SLGYAGVPMP EFSKLSIGFD KDHIANKQGR VLTSSGEIFP HLYASGWIRK GSQGVIASTM
430 440 450 460 470 480
QDAFEVGDRV IQDLVVSGAL SLENSIDLSN IKHTTWKDWE RINKKELLRG KKEHKTRSKF
490
LTFEELWNGV EGI