P48237
Gene name |
CCM1 (DMR1, RRG2, YGR150C, G6642) |
Protein name |
Mitochondrial group I intron splicing factor CCM1 |
Names |
COB and COX1 mRNA maturation protein 1, Required for respiratory growth protein 2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR150C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P48237
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8D8J | EM | 380 A | d | 1-864 | PDB |
| 8D8K | EM | 313 A | d | 1-864 | PDB |
| AF-P48237-F1 | Predicted | AlphaFoldDB |
19 variants for P48237
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-793036 | 8 | P>L | No | SGRP | |
| s07-793000 | 20 | S>C | No | SGRP | |
| s07-792932 | 43 | N>D | No | SGRP | |
| s07-792920 | 47 | S>G | No | SGRP | |
| s07-792797 | 88 | H>Y | No | SGRP | |
| s07-792736 | 108 | T>I | No | SGRP | |
| s07-792671 | 130 | E>K | No | SGRP | |
| s07-792409 | 217 | K>R | No | SGRP | |
| s07-792297 | 254 | L>F | No | SGRP | |
| s07-792229 | 277 | S>C | No | SGRP | |
| s07-791848 | 404 | S>F | No | SGRP | |
| s07-791725 | 445 | L>S | No | SGRP | |
| s07-791707 | 451 | A>V | No | SGRP | |
| s07-791470 | 530 | R>K | No | SGRP | |
| s07-791321 | 580 | M>L | No | SGRP | |
| s07-791264 | 599 | D>N | No | SGRP | |
| s07-790984 | 692 | S>L | No | SGRP | |
| s07-790955 | 702 | S>A | No | SGRP | |
| s07-790946 | 705 | A>T | No | SGRP |
No associated diseases with P48237
1 regional properties for P48237
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Pentatricopeptide repeat | 355 - 403 | IPR002885 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| rRNA binding | Binding to a ribosomal RNA. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial genome maintenance | The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. |
| mitochondrial RNA processing | The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| positive regulation of rRNA processing | Any process that activates or increases the frequency, rate or extent of rRNA processing. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| rRNA metabolic process | The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYMARCGPKN | NVLCFPFQLS | FLFSKRLINK | RFKYTLQTED | EKNMMGSLSK | NKIITPEDVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FKLAQLREFS | NTLKERIHNT | KSVNSDGHQS | NSIAPISEDS | RNVNVTKTSS | VPNEEKSKNL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SDLIHSSFLE | KMDHLVPKVI | RERVADDDIL | AKNLFDRSHS | NWAPVIDRLY | VSEKRFMDID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SREFSVWLNG | TVKYLPFHSI | LHLDEMLLEQ | INGDVVKFNT | HMYECIFNNL | GNLKPTNFNQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DGTNDKVILK | MKELLERYDK | ALKITEERIN | KKEGFPSKVP | KMTQAILNNC | LKYSTKCSSF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HDMDYFITKF | RDDYGITPNK | QNLTTVIQFY | SRKEMTKQAW | NTFDTMKFLS | TKHFPDICTY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NTMLRICEKE | RNFPKALDLF | QEIQDHNIKP | TTNTYIMMAR | VLASSSSNAV | VSEGKSDSLR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLGWKYLHEL | EDKNLYRHKK | DDLNLFLAMM | ALAAFDGDIE | LSRALYYLFI | AKKYKTLCAN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WKGNILVDQD | TIWKSTLMPE | MLNYLMLAYA | RFDPRNLPVL | SGYEKGIELR | RKFLREFDSS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MRLDDTDKLV | KFKLPFLPIS | DLNSEAQVLA | ESNAIWSFNM | ENGGTRNTLT | SSNEAALEDI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KKYRQLLDSF | AQEAEDFNEF | KFKVMYEVTK | MQRESINVNV | FNKISLHTYL | SIPINLKQQK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EFLRRLTFFT | FQQHEFEAVI | KRLYEGYRNI | PSSHTRDQNS | ISTEAISVSK | PETTEDLNLI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MHDIWYITCL | RHKIMMDTTL | YELVMKAAIE | FQNEDLAKKV | WNDRGKFRTT | VPFLKMDQRI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RIAKDQKFAH | LMVEFFTKQG | KYSDAIAIIL | SSKNRFNWTY | SMVRNLHKAL | EEIEDRNSVE |
| 850 | 860 | ||||
| ILLDVVNKKS | HAKALKWEEQ | ELNM |