P47843

PR
Gene name
SLC2A3
Protein name
Solute carrier family 2, facilitated glucose transporter member 3
Names
Glucose transporter type 3, brain, GLUT-3
Species
Ovis aries (Sheep)
KEGG Pathway
oas:443308
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

438-494 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P47843

Entry ID Method Resolution Chain Position Source
AF-P47843-F1 Predicted AlphaFoldDB

6 variants for P47843

Variant ID(s) Position Change Description Diseaes Association Provenance
rs159907333 16 I>V No Ensembl
rs1092933181 54 P>L No Ensembl
rs589436736 62 L>Q No Ensembl
rs1092159897 110 F>L No Ensembl
rs1085683818 218 E>G No Ensembl
rs422144910 444 V>I No Ensembl

No associated diseases with P47843

3 regional properties for P47843

Type Name Position InterPro Accession
conserved_site Sugar transporter, conserved site 126 - 151 IPR005829-1
conserved_site Sugar transporter, conserved site 322 - 338 IPR005829-2
domain Major facilitator superfamily domain 13 - 454 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Perikaryon
  • Cell projection
  • Localized to densely spaced patches along neuronal processes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
acrosomal membrane The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.

5 GO annotations of molecular function

Name Definition
D-glucose transmembrane transporter activity Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other.
dehydroascorbic acid transmembrane transporter activity Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other.
galactose transmembrane transporter activity Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
glucose binding Binding to D- or L-enantiomers of glucose.
glucose transmembrane transporter activity Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
galactose transmembrane transport The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
glucose transmembrane transport The process in which glucose is transported across a membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGTTKVTTPL IFAISIATIG SFQFGYNTGV INAPEAIIKD FLNYTLEERS ETPPSSVLLT
70 80 90 100 110 120
SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL AIAGGCLMGF CKIAESVEML
130 140 150 160 170 180
ILGRLIIGLF CGLCTGFVPM YIGEISPTAL RGAFGTLNQL GIVIGILVAQ IFGLKVILGT
190 200 210 220 230 240
EDLWPLLLGF TILPAIIQCA ALPFCPESPR FLLINRKEEE KAKEILQRLW GTEDVAQDIQ
250 260 270 280 290 300
EMKDESMRMS QEKQVTVLEL FRAPNYRQPI IISIMLQLSQ QLSGINAVFY YSTGIFKDAG
310 320 330 340 350 360
VQEPVYATIG AGVVNTIFTV VSVFLVERAG RRTLHLIGLG GMAFCSILMT ISLLLKDNYS
370 380 390 400 410 420
WMSFICIGAI LVFVAFFEIG PGPIPWFIVA ELFGQGPRPA AMAVAGCSNW TSNFLVGLLF
430 440 450 460 470 480
PSATFYLGAY VFIVFTVFLV IFWVFTFFKV PETRGRTFEE ITRAFEGQVQ TGTRGEKGPI
490
MEMNSIQPTK DTNA