AiPD: Autoinhibited Protein Database

Gene name	Gsr (Gr1)
Protein name	Glutathione reductase, mitochondrial
Names	GR, GRase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:14782
EC number	1.8.1.7: With NAD(+) or NADP(+) as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-58 (Predicted disordered autoinhibitory region) PR

1-58 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P47791-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs216776909	13	A>T	No	EVA
rs255696376	26	A>T	No	EVA
rs222992810	39	D>A	No	EVA
rs3388456318	120	V>A	No	EVA
rs3388982973	138	N>T	No	EVA
rs3388457411	148	I>F	No	EVA
rs3388456357	156	D>G	No	EVA
rs3388972562	166	G>E	No	EVA
rs3388971769	199	S>N	No	EVA
rs3388950973	204	Q>*	No	EVA
rs3388932121	206	E>K	No	EVA
rs3388950905	223	E>K	No	EVA
rs3388976965	225	A>E	No	EVA
rs3398908333	255	N>I	No	EVA
rs3398908283	258	E>V	No	EVA
rs3388975906	275	E>G	No	EVA
rs258792165	291	V>M	No	EVA
rs3398457404	292	P>S	No	EVA
rs3388979338	297	T>N	No	EVA
rs3388457418	300	M>T	No	EVA
rs33243735	300	M>V	No	EVA
rs3388975766	312	G>V	No	EVA
rs3388960527	316	N>K	No	EVA
rs3388979852	328	Q>K	No	EVA
rs3398976555	355	C>L	No	EVA
rs3398638697	363	V>A	No	EVA
rs3388983892	391	T>I	No	EVA
rs3388932095	392	V>M	No	EVA
rs3388982972	398	P>H	No	EVA
rs3388966447	398	P>S	No	EVA
rs3388979337	466	L>Q	No	EVA

Type	Name	Position	InterPro Accession
domain	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	389 - 499	IPR004099
active_site	Pyridine nucleotide-disulphide oxidoreductase, class I, active site	77 - 87	IPR012999
domain	FAD/NAD(P)-binding domain	43 - 368	IPR023753

		Description
EC Number	1.8.1.7	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	[Isoform Mitochondrial]: Mitochondrion ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
glutathione binding	Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
glutathione-disulfide reductase (NADPH) activity	Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.
identical protein binding	Binding to an identical protein or proteins.
NADP binding	Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

Name	Definition
cell redox homeostasis	Any process that maintains the redox environment of a cell or compartment within a cell.
cellular response to oxidative stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
glutathione metabolic process	The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins