Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P47747
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P47747-F1 | Predicted | AlphaFoldDB |
No variants for P47747
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P47747 | |||||
No associated diseases with P47747
1 regional properties for P47747
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 35 - 288 | IPR017452 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| histamine receptor activity | Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| gastric acid secretion | The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. |
| positive regulation of vasoconstriction | Any process that activates or increases the frequency, rate or extent of vasoconstriction. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFNGTVPSF | CMDFTVYKVT | ISVILIILIL | VTVAGNVVVC | LAVGLNRRLR | SLTNCFIVSL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AVTDLLLGLL | VLPFSAIYQL | SCKWSFSKVF | CNIYTSLDVM | LCTASILNLF | MISLDRYCAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TDPLRYPVLI | TPARVAISLV | FIWVISITLS | FLSIHLGWNS | RNETSKDNDT | IVKCKVQVNE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VYGLVDGLVT | FYLPLLIMCI | TYFRIFKIAR | EQARRINHIG | SWKAATIREH | KATVTLAAVM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GAFIICWFPY | FTVFVYRGLK | GDDAVNEVFE | DVVLWLGYAN | SALNPILYAA | LNRDFRTAYH |
| 310 | 320 | 330 | 340 | 350 | |
| QLFCCRLASH | NSHETSLRLN | NSQLNRSQCQ | EPRWQEDKPL | NLQVWSGTEV | TAPQGATNR |