P47729

PR
Gene name
polC
Protein name
DNA polymerase III PolC-type
Names
PolIII
Species
Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis)
KEGG Pathway
mpu:MYPU_6750
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

136-223 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P47729

Entry ID Method Resolution Chain Position Source
AF-P47729-F1 Predicted AlphaFoldDB

No variants for P47729

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P47729

No associated diseases with P47729

8 regional properties for P47729

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 312 - 380 IPR003141
domain PHP domain 314 - 676 IPR004013
domain DNA polymerase III epsilon subunit, exonuclease domain 401 - 616 IPR006054
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 815 - 1007 IPR011708-1
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 1019 - 1084 IPR011708-2
domain Exonuclease, RNase T/DNA polymerase III 403 - 571 IPR013520
domain DNA polymerase, helix-hairpin-helix motif 1364 - 1428 IPR029460
domain DNA polymerase III alpha subunit finger domain 1088 - 1240 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQESFLNFCQ EINFDIPEYL KNTKIANPYH DEEKSFFSCE IDFLETPKFE DFKSFYLKTK
70 80 90 100 110 120
NFLNQLVKEQ KLLFKIENIF YEKSEIKKYL DWIAEHFFKN FDFKNTFRID DLKVNLDGKI
130 140 150 160 170 180
FLTAHSKHSF DLYKDFVEFA NKKMQSFGFE NFLLKLELNQ IEITNNQPLV SSINSQVKTQ
190 200 210 220 230 240
ASSENQSFKK SNFYNKKRHI QLSLKELIKT QEMFVSVVGM VFKKEIITTN SKTKIFKISI
250 260 270 280 290 300
TDFQEATRAQ KFSYLEKDQE IFDSIQINDW VNVCGEIQLE KMSLKQFIKI EKIEKIRSPI
310 320 330 340 350 360
KDRQDNEKEK RIELSFRSKM STMDGILSPL DIVKQAKKFN HSSIAILDHN SVQAFPDFHN
370 380 390 400 410 420
LTYKDKDFKV IYGMTLSVIS KRNKIFVEPL KDKFFDYKIL DQEYVVYDIE TTGLSPMLNE
430 440 450 460 470 480
LIQFGASVIK NGRIIETHHF FIKPKSKLDS FTTKLTGITQ EHLEKGYELQ EALEKISSIF
490 500 510 520 530 540
KARIMVAHNA AFDHNFLKQK FIDNNIEFEE MISIDTLNLA KVLNPIYRSY RLGEVASKLS
550 560 570 580 590 600
VVYDPSIAHR ADYDSSVLTN IFILQMSHLK EKGINLFKEL NSLSSEKFYS KMFAKDISII
610 620 630 640 650 660
AKNQAGLKEL FKINSDVLTK YYFANPKMFW EDIKRSKNLL IGSGGLNSPL IDKLLFSTQE
670 680 690 700 710 720
DVLNEIDKYD YIEIPSPNNF SHFWTTKFSD QQIKIQLQKL IKWAKEKNKI IVAIGEPRYN
730 740 750 760 770 780
EKWQKIIHEI YINSTGIENS LHPLFIIKKD MDTFYPEQIY KTTNEMKQEF SFLYDPELIE
790 800 810 820 830 840
EIVVKNPNLI SSQIEKIQVI KDKLYTPKFD DSHIKLKKLV YENAWKKYGK NLPEIIEQRI
850 860 870 880 890 900
EKELTPILNY GFDVIYWISS ILVQKSLSDG YLVGSRGSIG SSLVATLSGI TEVNPLAPHY
910 920 930 940 950 960
ICSKCQYFEL VKDPMTNSGF DLDDKKCPKC NSFLDKDGQT IPFETFLGFK ADKVPDIDLN
970 980 990 1000 1010 1020
FSGEYQGKIH DEVKRLFGSK HTFRAGTIST VAEKTAYGYI KKYLETASLD YSDNFVDFLT
1030 1040 1050 1060 1070 1080
EKSTGVKRTT GQHPGGIIII PKEFDVEDFT PVNFPANDTE SSWKTTHFDF HAIHDNVLKL
1090 1100 1110 1120 1130 1140
DILGHDDPTA LKMLEKLTGV NVKDIPKKDE KIISIFTSPK ALGISSEEIL GEKTGALGIP
1150 1160 1170 1180 1190 1200
EFGTNFVRQM LSEAKPKTFA DLVSISGLSH GTDVWINNAH YIIQSLGKTL DQVISCRDDI
1210 1220 1230 1240 1250 1260
MVDLIKKGVP IDLSFTIMEQ VRKGKGLSLE QKRKLIEHGI ENWYIESMEK IKYMFPKAHA
1270 1280 1290 1300 1310 1320
TAYVLMAWRV AFYKVYYPLE YYATYFSTRT EFFDIEIMSK DKLTLESKIK ELAYRENLRN
1330 1340 1350 1360 1370 1380
DNQLTTKEKN TLPTLYIANE MKARGFNIQN INLKISLAND WIIDKNSKSL IPPFNVIDGL
1390 1400 1410 1420 1430
GETLAQKIVD SRNEKEFLSV EDFINRTGIN STLVEKFKSM GIFEQIPETN QIFLI