P47668

PR
Gene name
ptsI (MG429)
Protein name
Phosphoenolpyruvate-protein phosphotransferase
Names
Phosphotransferase system, enzyme I
Species
Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium)
KEGG Pathway
mge:MG_429
EC number
2.7.3.9: Phosphotransferases with a nitrogenous group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P47668

Entry ID Method Resolution Chain Position Source
AF-P47668-F1 Predicted AlphaFoldDB

No variants for P47668

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P47668

No associated diseases with P47668

6 regional properties for P47668

Type Name Position InterPro Accession
domain PEP-utilising enzyme, C-terminal 253 - 536 IPR000121
domain Phosphotransferase system, enzyme I-like 4 - 562 IPR006318
domain PEP-utilising enzyme, mobile domain 153 - 226 IPR008279
domain Phosphotransferase system, enzyme I N-terminal 6 - 127 IPR008731
active_site PEP-utilising enzyme, active site 185 - 196 IPR018274
conserved_site PEP-utilising enzyme, conserved site 443 - 461 IPR023151

Functions

Description
EC Number 2.7.3.9 Phosphotransferases with a nitrogenous group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
metal ion binding Binding to a metal ion.
phosphoenolpyruvate-protein phosphotransferase activity Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.

2 GO annotations of biological process

Name Definition
phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKIIGIGVS DGIAVAKAFI IQTPQFDVKK YTNVKMTPTQ AKKLLSSAFQ KAKKDLEEIK
70 80 90 100 110 120
TITVKNINQE AGMIFDAHIQ ILNDPTITEQ LEQQLNKNIH PVIAVDNVFQ QTALMFSEMD
130 140 150 160 170 180
DKYFKERASD ILDLHQRLLS YLTGVKLNDL IRIKSDVIIV ANDLTPSQTA TLNKKYVKGF
190 200 210 220 230 240
LTESGGKTSH AAIMARSMEI PAIVGLKNIT SKVEDGKTVG INGRKGIVGF DFSSKDITQW
250 260 270 280 290 300
KQEKELESNF QNELKQYTNK LVKTLDGYEV IVASNIGNVK DMDLAVEYNT NGIGLFRTEF
310 320 330 340 350 360
LYMSSQDWPD ESVQFEAYKT VLQKAKNDLV IIRTLDIGGD KKLNYFQFPH EDNPFLGYRA
370 380 390 400 410 420
IRLTLDKQAV FKTQLRALLR ASDYGNLGIM FPMVATLDEL VQVKQLLTKV QQEFNETKKF
430 440 450 460 470 480
KLGIMIEIPS AALAADCLGK HVDFFSIGSN DLIQYSFAAD RMNKNVSYLY QPLNPALLRL
490 500 510 520 530 540
IKLVVEGGKL NNVWTGMCGE MASDQYAIPL LLGLGLTELS MSASSMFKAR MVIAKITINE
550 560 570
CKSLVEKALK LTSDSAVRKL VENFFKKKNI FI