P47514

PR
Gene name
pdhC (MG272)
Protein name
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Names
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2
Species
Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium)
KEGG Pathway
mge:MG_272
EC number
2.3.1.12: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

56-170 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P47514

Entry ID Method Resolution Chain Position Source
AF-P47514-F1 Predicted AlphaFoldDB

No variants for P47514

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P47514

No associated diseases with P47514

3 regional properties for P47514

Type Name Position InterPro Accession
domain Biotin/lipoyl attachment 2 - 77 IPR000089
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 153 - 381 IPR001078
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 27 - 56 IPR003016

Functions

Description
EC Number 2.3.1.12 Transferring groups other than amino-acyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
acetyltransferase activity Catalysis of the transfer of an acetyl group to an acceptor molecule.
dihydrolipoyllysine-residue acetyltransferase activity Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.
lipoic acid binding Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid.

1 GO annotations of biological process

Name Definition
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MANEFKFTDV GEGLHEGKVT EILKQVGDQI KIDEALFVVE TDKVTTELPS PFAGTISAIN
70 80 90 100 110 120
VKVGDVVSIG QVMAVIGEKT STPLVEPKPQ PTEEVAKVKE AGASVVGEIK VSDNLFPIFG
130 140 150 160 170 180
VKPHATPAVK DTKVASSTNI TVETTQKPES KTEQKTIAIS TMRKAIAEAM TKSHAIIPTT
190 200 210 220 230 240
VLTFYVNATK LKQYRESVNG YALSKYSMKI SYFAFFVKAI VNALKKFPVF NASYDPDQNE
250 260 270 280 290 300
IVLNDDINVG IAVDTEEGLI VPNIKQAQTK SVVEIAQAIV DLANKARTKK IKLTDLNKGT
310 320 330 340 350 360
ISVTNFGSLG AAVGTPIIKY PEMCIVATGN LEERIVKVEN GIAVHTILPL TIAADHRWVD
370 380
GADVGRFGKE IAKQIEELID LTVA