P47416

PR
Gene name
secY
Protein name
Protein translocase subunit SecY
Names
Species
Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium)
KEGG Pathway
mge:MG_170
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

422-475 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P47416

Entry ID Method Resolution Chain Position Source
AF-P47416-F1 Predicted AlphaFoldDB

No variants for P47416

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P47416

No associated diseases with P47416

2 regional properties for P47416

Type Name Position InterPro Accession
conserved_site SecY conserved site 81 - 100 IPR030659-1
conserved_site SecY conserved site 181 - 198 IPR030659-2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cell envelope Sec protein transport complex A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
protein transmembrane transporter activity Enables the transfer of a protein from one side of a membrane to the other.
signal sequence binding Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.

2 GO annotations of biological process

Name Definition
protein transport by the Sec complex The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.
SRP-dependent cotranslational protein targeting to membrane, translocation The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQTVSSPKQK LNFGQRLLTL LQNRDFMVSL VLTVVLLILF RVLAIIPLPG IRINESVLDR
70 80 90 100 110 120
NSNDFFSLFN LLGGGGLNQL SLFAVGISPY ISAQIIMQLL STDLIPPLSK LVNSGEVGRR
130 140 150 160 170 180
KIEMITRIIT LPFALVQAFA VIQIATNAGT GSSPISLANS GSEFIAFYII AMTAGTYMAV
190 200 210 220 230 240
FLGDTISKKG VGNGITLLIL SGILSQLPQG FIAAYNVLSG IVITLTPQLT AAISFFIYFL
250 260 270 280 290 300
AFLVLLFATT FITQATRKIP IQQSGQGLVS EVKTLPYLPI KVNAAGVIPV IFASSIMSIP
310 320 330 340 350 360
VTIAQFQPQT ESRWFVEDYL SLSTPVGIFL YAVLVILFSF FYSYIQINPE RLAKNFEKSG
370 380 390 400 410 420
RFIPGIRPGN DTEKHIARVL IRINFIGAPF LTVIAIIPYI VSYFIRLPNS LSLGGTGIII
430 440 450 460 470
IVTAVVEFIS ALRSAATATN YQQLRRNLAI EVQQTAKQDS LEQLQKEAPG IGNLW