P47340
Gene name |
dnaB (MG094) |
Protein name |
Replicative DNA helicase |
Names |
|
Species |
Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium) |
KEGG Pathway |
mge:MG_094 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P47340
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P47340-F1 | Predicted | AlphaFoldDB |
No variants for P47340
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P47340 | |||||
No associated diseases with P47340
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| primosome complex | Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication, synthesis of RNA primer | The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis. |
| DNA unwinding involved in DNA replication | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGQQTSFKYA | NDSNIERAER | RLMQAVAQNS | EGIDLIFNKL | EPIDFFATPF | KLIFQTAKEN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YQLNNPIIGS | GLLEAVKFKL | DANDQSTKSE | LEILFTKILL | IRLPPNQTEI | KTLVDVVKKA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SIFRRLQQFA | KRVYNEEFKL | KEDRFEGYLQ | AIQDDFVKII | HSAFSNIFAF | SYDEIANQEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ALIKKVHRGE | LIISGLSSGF | LKLDQLTSGW | KPGELIVIAA | RPGRGKTALL | INFMASAAKQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IDPKTDVVLF | FSLEMRNREI | YQRHLMHESQ | TSYTLTNRQR | INNVFEELME | ASSRIKNLPI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLFDYSSLTL | QEIRNQITEV | SKTSNVRLVI | IDYLQLVNAL | KNNYGLTRQQ | EVTMISQSLK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFAKEFNTPI | IAAAQLSRRI | EERKDSRPIL | SDLRESGSIE | QDADMVLFIH | RTNDDKKEQE |
| 430 | 440 | 450 | 460 | ||
| EENTNLFEVE | LILEKNRNGP | NGKVKLNFRS | DTSSFISQYS | PSFDDQYS |