P47250

PR
Gene name
gyrA
Protein name
DNA gyrase subunit A
Names
Species
Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium)
KEGG Pathway
mge:MG_004
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P47250

Entry ID Method Resolution Chain Position Source
AF-P47250-F1 Predicted AlphaFoldDB

No variants for P47250

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P47250

No associated diseases with P47250

7 regional properties for P47250

Type Name Position InterPro Accession
domain DNA topoisomerase, type IIA, domain A 23 - 485 IPR002205
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 517 - 562 IPR006691-1
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 566 - 615 IPR006691-2
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 621 - 661 IPR006691-3
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 668 - 711 IPR006691-4
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 720 - 760 IPR006691-5
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 769 - 812 IPR006691-6

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKQQDQVDK IRENLDNSTV KSISLANELE RSFMEYAMSV IVARALPDAR DGLKPVHRRV
70 80 90 100 110 120
LYGAYIGGMH HDRPFKKSAR IVGDVMSKFH PHGDMAIYDT MSRMAQDFSL RYLLIDGHGN
130 140 150 160 170 180
FGSIDGDRPA AQRYTEARLS KLAAELLKDI DKDTVDFIAN YDGEEKEPTV LPAAFPNLLA
190 200 210 220 230 240
NGSSGIAVGM STSIPSHNLS ELIAGLIMLI DNPQCTFQEL LTVIKGPDFP TGANIIYTKG
250 260 270 280 290 300
IESYFETGKG NVVIRSKVEI EQLQTRSALV VTEIPYMVNK TTLIEKIVEL VKAEEISGIA
310 320 330 340 350 360
DIRDESSREG IRLVIEVKRD TVPEVLLNQL FKSTRLQVRF PVNMLALVKG APVLLNMKQA
370 380 390 400 410 420
LEVYLDHQID VLVRKTKFVL NKQQERYHIL SGLLIAALNI DEVVAIIKKS ANNQEAINTL
430 440 450 460 470 480
NTKFKLDEIQ AKAVLDMRLR SLSVLEVNKL QTEQKELKDS IEFCKKVLAD QKLQLKIIKE
490 500 510 520 530 540
ELQKINDQFG DERRSEILYD ISEEIDDESL IKVENVVITM STNGYLKRIG VDAYNLQHRG
550 560 570 580 590 600
GVGVKGLTTY VDDSISQLLV CSTHSDLLFF TDKGKVYRIR AHQIPYGFRT NKGIPAVNLI
610 620 630 640 650 660
KIEKDERICS LLSVNNYDDG YFFFCTKNGI VKRTSLNEFI NILSNGKRAI SFDDNDTLYS
670 680 690 700 710 720
VIKTHGNDEI FIGSTNGFVV RFHENQLRVL SRTARGVFGI SLNKGEFVNG LSTSSNGSLL
730 740 750 760 770 780
LSVGQNGIGK LTSIDKYRLT KRNAKGVKTL RVTDRTGPVV TTTTVFGNED LLMISSAGKI
790 800 810 820 830
VRTSLQELSE QGKNTSGVKL IRLKDNERLE RVTIFKEELE DKEMQLEDVG SKQITQ