P47235

PR
Gene name
gyrA
Protein name
DNA gyrase subunit A
Names
Species
Campylobacter fetus
KEGG Pathway
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

492-566 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P47235

Entry ID Method Resolution Chain Position Source
AF-P47235-F1 Predicted AlphaFoldDB

No variants for P47235

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P47235

No associated diseases with P47235

7 regional properties for P47235

Type Name Position InterPro Accession
domain DNA topoisomerase, type IIA, domain A 15 - 477 IPR002205
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 507 - 551 IPR006691-1
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 556 - 605 IPR006691-2
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 613 - 657 IPR006691-3
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 694 - 740 IPR006691-4
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 745 - 792 IPR006691-5
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 797 - 841 IPR006691-6

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.

3 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEENIFSSNQ DIDAIDVEDS IKASYLDYSM SVIIGRALPD ARDGLKPVHR RILYAMNDLG
70 80 90 100 110 120
VGSRSPYKKS ARIVGDVIGK YHPHGDTAVY DALVRMAQNF SMRVPAVDGQ GNFGSVDGDG
130 140 150 160 170 180
AAAMRYTEAR MTVLAEELLR DLDKDTVDFI PNYDDSLSEP DVLPARVPNL LLNGSSGIAV
190 200 210 220 230 240
GMATNIPPHS LDELVNGLLT LLDDKEVGLE DIMTHIKGPD FPTGGIIFGK KGIIEAYKTG
250 260 270 280 290 300
RGRIKLRAKT HIEKKPNKDV IVVDELPYQV NKAKLHADIA DLVKEKLIDG ISEVRDESDR
310 320 330 340 350 360
DGIRLVIELK RDAMSEIVLN NLFKSTQMEV TFGVIMLAIN NKEPKVFSLL ELLKLFLNHR
370 380 390 400 410 420
KTVIIRRTIF ELQKARARAH ILEGLKIALD NIDAVINLIK TSADTNSARD GLMAKFGLSE
430 440 450 460 470 480
LQSNAILDMR LSKLTGLERE KLEAELKEIL ELIEKLDAIL KSETLIENII RDELLEIKSK
490 500 510 520 530 540
FKCPRITDIV DDYDDIDVED LIPNENMVVT ITHRGYIKRV PSKSYEKQKR GGKGKVAVTT
550 560 570 580 590 600
YDDDFIESFF TCMSHDTLMF VTDRGQLYWL KVYKIPEGSR TAKGKAVVNL ISLQADEKIK
610 620 630 640 650 660
AIIPTTDFDE SKSLAFFTKN GIVKRTNLSE FKNIRSIGVK AINLDDNDEL VTVVIANSEP
670 680 690 700 710 720
DESYDDSFED GEGVSNLQTI SEDNSENSLE SGKMLFAVTK KGMCIKFALN KVRQIGRVSR
730 740 750 760 770 780
GVTAIRFKEN LDEVVGAVVI ENDSQEILSV SQKGIGKRTT ADEYRLQSRG GKGVICMKLT
790 800 810 820 830 840
PKTKDLVGVV MVDEEMDLMA LTSSGKMIRV DMQSIRKAGR NTSGVIVVNV DGDEVVSIAR
850 860
CPKEESDDDD IVADDTQEQD ME