P47195
Gene name |
CYP80A1 (CYP80) |
Protein name |
Berbamunine synthase |
Names |
(S)-N-methylcoclaurine oxidase [C-O phenol-coupling], CYPLXXX, Cytochrome P450 80 |
Species |
Berberis stolonifera (Barberry) |
KEGG Pathway |
ag:AAC48987 |
EC number |
1.14.19.66: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P47195
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P47195-F1 | Predicted | AlphaFoldDB |
No variants for P47195
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P47195 | |||||
No associated diseases with P47195
1 regional properties for P47195
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 422 - 431 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.19.66 | With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| berbamunine synthase activity | Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine |
| heme binding | +Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| berbamunine biosynthetic process | The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDYIVGFVSI | SLVALLYFLL | FKPKHTNLPP | SPPAWPIVGH | LPDLISKNSP | PFLDYMSNIA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QKYGPLIHLK | FGLHSSIFAS | TKEAAMEVLQ | TNDKVLSGRQ | PLPCFRIKPH | IDYSILWSDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NSYWKKGRKI | LHTEIFSQKM | LQAQEKNRER | VAGNLVNFIM | TKVGDVVELR | SWLFGCALNV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGHVVFSKDV | FEYSDQSDEV | GMDKLIHGML | MTGGDFDVAS | YFPVLARFDL | HGLKRKMDEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FKLLIKIWEG | EVLARRANRN | PEPKDMLDVL | IANDFNEHQI | NAMFMETFGP | GSDTNSNIIE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WALAQLIKNP | DKLAKLREEL | DRVVGRSSTV | KESHFSELPY | LQACVKETMR | LYPPISIMIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HRCMETCQVM | GYTIPKGMDV | HVNAHAIGRD | PKDWKDPLKF | QPERFLDSDI | EYNGKQFQFI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PFGSGRRICP | GRPLAVRIIP | LVLASLVHAF | GWELPDGVPN | EKLDMEELFT | LSLCMAKPLR |
| VIPKVRI |