P47124
Gene name |
HOC1 (YJR075W, J1830) |
Protein name |
Putative glycosyltransferase HOC1 |
Names |
M-Pol II subunit Hoc1p, Mannan polymerase II complex HOC1 subunit |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YJR075W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P47124
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P47124-F1 | Predicted | AlphaFoldDB |
4 variants for P47124
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s10-574018 | 15 | M>I | No | SGRP | |
| s10-574103 | 44 | I>V | No | SGRP | |
| s10-574298 | 109 | P>S | No | SGRP | |
| s10-574833 | 287 | T>S | No | SGRP |
No associated diseases with P47124
No regional properties for P47124
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P47124 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mannan polymerase complex | A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-1,6-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall mannoprotein biosynthetic process | The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues. |
| protein N-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. |
| substituted mannan metabolic process | The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKTTKRASS | FRRLMIFAII | ALISLAFGVR | YLFHNSNATD | LQKILQNLPK | EISQSINSAN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NIQSSDSDLV | QHFESLAQEI | RHQQEVQAKQ | FDKQRKILEK | KIQDLKQTPP | EATLRERIAM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TFPYDSHVKF | PAFIWQTWSN | DEGPERVQDI | KGMWESKNPG | FAHEVLNHDV | INALVHHYFY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SIPEILETYE | ALPSIILKID | FFKYLILLVH | GGVYADIDTF | PVQPIPNWIP | EELSPSDIGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IVGVEEDAQR | ADWRTKYIRR | LQFGTWIIQA | KPGHPVLREI | ISRIIETTLQ | RKRDDQLNVN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRNDLNIMSW | TGSGLWTDTI | FTYFNDFMRS | GVREKVTWKL | FHNLNQPKLL | SDVLVFPKFS |
| 370 | 380 | 390 | |||
| FNCPNQIDND | DPHKKFYFIT | HLASQFWKNT | PKVEQK |