P46997

PR
Gene name
JJJ2 (YJL162C, J0549)
Protein name
J protein JJJ2
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJL162C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-493 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P46997

Entry ID Method Resolution Chain Position Source
AF-P46997-F1 Predicted AlphaFoldDB

19 variants for P46997

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-115318 103 G>A No SGRP
s10-114997 210 A>V No SGRP
s10-114919 236 E>G No SGRP
s10-114827 267 K>Q No SGRP
s10-114821 269 N>D No SGRP
s10-114809 273 P>S No SGRP
s10-114760 289 T>M No SGRP
s10-114701 309 S>P No SGRP
s10-114633 331 K>N No SGRP
s10-114619 336 K>R No SGRP
s10-114597 343 E>D No SGRP
s10-114578 350 A>T No SGRP
s10-114520 369 V>E No SGRP
s10-114289 446 K>R No SGRP
s10-114271 452 S>N No SGRP
s10-114248 460 A>T No SGRP
s10-114170 486 E>Q No SGRP
s10-114061 522 Q>R No SGRP
s10-113993 545 M>L No SGRP

No associated diseases with P46997

2 regional properties for P46997

Type Name Position InterPro Accession
domain DnaJ domain 12 - 77 IPR001623
conserved_site DnaJ domain, conserved site 54 - 73 IPR018253

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
unfolded protein binding Binding to an unfolded protein.

2 GO annotations of biological process

Name Definition
chaperone cofactor-dependent protein refolding The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.
protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P36659 cbpA Curved DNA-binding protein Escherichia coli (strain K12) PR
10 20 30 40 50 60
MSQVIEPQLD RTTYYSILGL TSNATSSEVH KSYLKLARLL HPDKTKSDKS EELFKAVVHA
70 80 90 100 110 120
HSILTDEDQK LRYDRDLKIK GLHTYQPKKN CHIFKTKAKE SQGASPTLGQ SEAYHRQNKP
130 140 150 160 170 180
YEQQPYGFGV GKKMTSSSKS KVPIFKSFNL KSYQRNHYYS SKKERKHGSP DIDSLFHETN
190 200 210 220 230 240
GASKVRMTDA GKMDTNSQFQ EIWEILGKNA YTHKSYSEDP NSCLGSALSD HEEEEEAGKQ
250 260 270 280 290 300
QQQQQQQQQQ QQHYGMTSKS SSPDEEKKNN KEPKRESRVS PEENGEEETG HKQFKLPKTS
310 320 330 340 350 360
TFSSGSHDSN LQSPFYNHEY RHYARSKFEC KNQFRKSVSP IKEIPATTSA NEGWNILRDI
370 380 390 400 410 420
IEKLNISNVD DRNKDLLFRR DEIGDKNHSD SIDIENLSIK EPKGMKRRKK DDISLEELFQ
430 440 450 460 470 480
SLPREKDYFM MDAINDSLES INLFKKPKTT QSHEQGGTFA QAESNRAKFK PLLEQCGITP
490 500 510 520 530 540
EILDLEIPEI PEFDAVADLE TLKLNVQLFN NQCNKLKETI HQVSLQRLRA DTQFSDMLTQ
550 560 570 580
KQSIMVWKTY LEFDKSLMDK LNILQERQMQ VIKIFSERCD GKV