P46861

PR
Gene name
lysS (ML0233)
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML0233
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P46861

Entry ID Method Resolution Chain Position Source
AF-P46861-F1 Predicted AlphaFoldDB

No variants for P46861

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P46861

No associated diseases with P46861

9 regional properties for P46861

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (D/K/N) 158 - 501 IPR004364
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 66 - 142 IPR004365
domain Aminoacyl-tRNA synthetase, class II 186 - 504 IPR006195
domain Lysyl-tRNA synthetase, class II, C-terminal 195 - 205 IPR018149-1
domain Lysyl-tRNA synthetase, class II, C-terminal 211 - 227 IPR018149-2
domain Lysyl-tRNA synthetase, class II, C-terminal 240 - 253 IPR018149-3
domain Lysyl-tRNA synthetase, class II, C-terminal 258 - 275 IPR018149-4
domain Lysyl-tRNA synthetase, class II, C-terminal 388 - 404 IPR018149-5
domain Lysine-tRNA ligase, class II, N-terminal 63 - 170 IPR044136

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
magnesium ion binding Binding to a magnesium (Mg) ion.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNADPLETDA ALPEQFRIRR DKRARLLAEG RDPYPVAIER THTLAEVRAA YPDLATDSAT
70 80 90 100 110 120
DDIVGIAGRV IFARNSGKLC FATLQDGDGT NLQVMISLNK VGSETLDAWK VDVDLGDIVY
130 140 150 160 170 180
VHGNVISSRS GELSVLADSW QMVSKSLRPL PVAHKEMSEE SRVRQRYVDL IVCPQVRIVA
190 200 210 220 230 240
HQRIAVIRAI RTALERRGFL EVETPMLQTL AGGAAARPFV THSNALDIDL YLRIAPELFL
250 260 270 280 290 300
KRCIVGGFDK VFELNRVFRN EGADSTHSPE FSMLETYQTY GTYDDSAVVT REIIQEVADE
310 320 330 340 350 360
AIGTRQLQMP DDSVYDIDGE WETIQMYPSL SAVLGEEITP QTSVDRLRAI ADRLGRGIGP
370 380 390 400 410 420
EILDKPSYGH GRLVEQLWEY TVGNTLSAPT FVKDFPVETT PLTRQHRSIP GVTEKWDLYL
430 440 450 460 470 480
RGVELATGYS ELNDPVVQRE RFGQQVRAAA AEEDEAMALD EEFLAALEYA MPPCTGTGMG
490 500
IDRLLMSLTG LSIRETVLFP IVRPHSN