P46799

PR
Gene name
topA
Protein name
DNA topoisomerase 1
Names
DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tma:TM0258
EC number
5.6.2.1: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

197-272 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P46799

Entry ID Method Resolution Chain Position Source
2GAI X-ray 170 A A/B 3-633 PDB
2GAJ X-ray 195 A A/B 3-633 PDB
AF-P46799-F1 Predicted AlphaFoldDB

No variants for P46799

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P46799

No associated diseases with P46799

7 regional properties for P46799

Type Name Position InterPro Accession
domain DNA topoisomerase, type IA, domain 2 105 - 193 IPR003601
domain DNA topoisomerase, type IA, DNA-binding domain 233 - 495 IPR003602
domain TOPRIM domain 6 - 115 IPR006171
domain DNA topoisomerase, type IA, central 79 - 92 IPR013497-1
domain DNA topoisomerase, type IA, central 128 - 543 IPR013497-2
active_site DNA topoisomerase, type IA, active site 270 - 292 IPR023406
domain DNA topoisomerase 1, TOPRIM domain 6 - 126 IPR034149

Functions

Description
EC Number 5.6.2.1 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKKVKKYIV VESPAKAKTI KSILGNEYEV FASMGHIIDL PKSKFGVDLE KDFEPEFAVI
70 80 90 100 110 120
KGKEKVVEKL KDLAKKGELL IASDMDREGE AIAWHIARVT NTLGRKNRIV FSEITPRVIR
130 140 150 160 170 180
EAVKNPREID MKKVRAQLAR RILDRIVGYS LSPVLWRNFK SNLSAGRVQS ATLKLVCDRE
190 200 210 220 230 240
REILRFVPKK YHRITVNFDG LTAEIDVKEK KFFDAETLKE IQSIDELVVE EKKVSVKKFA
250 260 270 280 290 300
PPEPFKTSTL QQEAYSKLGF SVSKTMMIAQ QLYEGVETKD GHIAFITYMR TDSTRVSDYA
310 320 330 340 350 360
KEEARNLITE VFGEEYVGSK RERRKSNAKI QDAHEAIRPT NVFMTPEEAG KYLNSDQKKL
370 380 390 400 410 420
YELIWKRFLA SQMKPSQYEE TRFVLRTKDG KYRFKGTVLK KIFDGYEKVW KTERNTGEFP
430 440 450 460 470 480
FEEGESVKPV VVKIEEQETK PKPRYTEGSL VKEMERLGIG RPSTYASTIK LLLNRGYIKK
490 500 510 520 530 540
IRGYLYPTIV GSVVMDYLEK KYSDVVSVSF TAEMEKDLDE VEQGKKTDKI VLREFYESFS
550 560 570 580 590 600
SVFDRNDRIV VDFPTNQKCS CGKEMRLSFG KYGFYLKCEC GKTRSVKNDE IAVIDDGKIF
610 620 630
LGRKDSESGS PDGRSVEGKG NLSEKRRKGK KGS