P46661

PR
Gene name
IL12A
Protein name
Interleukin-12 subunit alpha
Names
IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35
Species
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

144-213 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P46661

Entry ID Method Resolution Chain Position Source
AF-P46661-F1 Predicted AlphaFoldDB

No variants for P46661

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P46661

No associated diseases with P46661

4 regional properties for P46661

Type Name Position InterPro Accession
domain Homeobox domain 198 - 262 IPR001356
conserved_site Homeobox, conserved site 233 - 256 IPR017970
domain Homeobox domain, metazoa 222 - 233 IPR020479-1
domain Homeobox domain, metazoa 237 - 256 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

3 GO annotations of molecular function

Name Definition
cytokine activity The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
interleukin-12 receptor binding Binding to an interleukin-12 receptor.

1 GO annotations of biological process

Name Definition
immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MCPARSLLLV ATLVLLDYLS LARNLSVATP GPEMFPCLHH SQNLLKAACN TLQKARQILE
70 80 90 100 110 120
FYPCTSEEID HEDITKDKTS TVEACLPLEL IKNESCLNSR ETSVITNGSC LASRKTSFMM
130 140 150 160 170 180
ALCLRSIYED LKIYQVEFKT MNAKLLMDPK RQIFLDQNIL GVIDELMQAL NFNSETVPQK
190 200 210
SSLEEPDFYK TKIKLCILLH AFKIRAVTID RVMSYLNAS