P46585

PR
Gene name
PRS1
Protein name
Ribose-phosphate pyrophosphokinase 1
Names
Phosphoribosyl pyrophosphate synthase 1
Species
Candida albicans (Yeast)
KEGG Pathway
EC number
2.7.6.1: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P46585

Entry ID Method Resolution Chain Position Source
AF-P46585-F1 Predicted AlphaFoldDB

No variants for P46585

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P46585

No associated diseases with P46585

3 regional properties for P46585

Type Name Position InterPro Accession
domain Phosphoribosyltransferase domain 154 - 276 IPR000836
conserved_site Phosphoribosyl pyrophosphate synthetase, conserved site 131 - 146 IPR000842
domain Ribose-phosphate pyrophosphokinase, N-terminal domain 6 - 123 IPR029099

Functions

Description
EC Number 2.7.6.1 Diphosphotransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
ribose phosphate diphosphokinase complex A protein complex having ribose phosphate diphosphokinase activity.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
magnesium ion binding Binding to a magnesium (Mg) ion.
ribose phosphate diphosphokinase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+).

5 GO annotations of biological process

Name Definition
5-phosphoribose 1-diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.
fungal-type cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTNSIKLLA SDVHRGLAEL VSKRLGLRLT PSELKRESTG EVQFSIGESV RDEDIFIICQ
70 80 90 100 110 120
IGSGEVNDRV FELMIMINAC KTASARRITV ILPNFPYARQ DRKDKSRAPI TAKLMADMLT
130 140 150 160 170 180
TAGCDHVITM DLHASQIQGF FDVPVDNLYA EPSVVRYIKE TIDYSEAIII SSDAGGAKRA
190 200 210 220 230 240
AGLADRLDLN FELIHKERAR ANEVSRMVLV VDVTDKICVI VDDMADTCGT LAKAAEVLLD
250 260 270 280 290 300
NNAKDVIAIV THGILSGNAI KNINNSKLKK VVCTNTVPFE DKLKLCLKLD TIDISAVIAE
310 320
SIRRLHNGES ISYLFKNAPC K