P46472

PR
Gene name
psmc2 (mss1)
Protein name
26S proteasome regulatory subunit 7
Names
26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2, xMSS1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:399327
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-228 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P46472

Entry ID Method Resolution Chain Position Source
AF-P46472-F1 Predicted AlphaFoldDB

No variants for P46472

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P46472

No associated diseases with P46472

4 regional properties for P46472

Type Name Position InterPro Accession
domain AAA+ ATPase domain 208 - 347 IPR003593
domain ATPase, AAA-type, core 212 - 344 IPR003959
conserved_site ATPase, AAA-type, conserved site 315 - 333 IPR003960
domain AAA ATPase, AAA+ lid domain 367 - 411 IPR041569

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome accessory complex A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

1 GO annotations of biological process

Name Definition
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPDYLGADQR KTKEEEKEDK PIRSLDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN
70 80 90 100 110 120
ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK
130 140 150 160 170 180
FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC
190 200 210 220 230 240
KEQIEKLREV VETPLLHPER FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV
250 260 270 280 290 300
IGSELVQKYV GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML
310 320 330 340 350 360
ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG RTHIFKIHAR
370 380 390 400 410 420
SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR RKVATEKDFL EAVNKVIKSY
430
AKFSATPRYM TYN