P46344

PR
Gene name
pgpH
Protein name
Cyclic-di-AMP phosphodiesterase PgpH
Names
c-di-AMP phosphodiesterase
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU25330
EC number
3.1.4.59: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

34-226 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P46344

Entry ID Method Resolution Chain Position Source
AF-P46344-F1 Predicted AlphaFoldDB

No variants for P46344

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P46344

No associated diseases with P46344

5 regional properties for P46344

Type Name Position InterPro Accession
domain HD/PDEase domain 497 - 663 IPR003607
domain HD domain 501 - 643 IPR006674
domain HDIG domain 498 - 596 IPR006675
domain Metal-dependent phosphohydrolase, 7TM intracellular domain 277 - 476 IPR011621
domain Metal-dependent phosphohydrolase, 7TM extracellular domain 54 - 270 IPR011624

Functions

Description
EC Number 3.1.4.59 Phosphoric diester hydrolases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
cyclic-di-AMP phosphodiesterase activity Catalysis of the reaction: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-5')-adenosine + H+.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
metal ion binding Binding to a metal ion.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKKKAKTKS SSKKWSSFKN ARSMHVLLYL LLAAIMFALL FVHVKPETLD LDLFSVSDKT
70 80 90 100 110 120
IYAPATVEDQ KATEEKKQAA EDAVEDQYTL KKEYTDNRID LVSSIFDSIS EVKKSSEEGS
130 140 150 160 170 180
KSPSEKSMVK SVKDKLTSDV NDSISEDSIK TLLKADSEDF SFVRDTVITA VNTVMSSEIP
190 200 210 220 230 240
SDKLSDAKDK VEKELKSNSI PSKYLGAATE IGRFAIIPNY VFDPKATEAK RQEASDNVQQ
250 260 270 280 290 300
VQIKQGQVLV EENDLIDREV YRKLELTGLL NNSNLFKPIS GLLIMIGLFI ATLVYYFEKQ
310 320 330 340 350 360
KQNLKFKNQS ILLFSIITTL LLVIMEVVSL FQKMEYNNIG YLVPIAAGAI LIKLLMNERI
370 380 390 400 410 420
AILGSIILAI CGSMMFNQGV TGTFNYVIGI YYLISGISGV LFLGKHNARS KILQTGLFVA
430 440 450 460 470 480
FINMVVVLSL LLIQNTALSG LEIGTLMLMG VVSGFASSVL IIGLMPFFET GFGILSTMRL
490 500 510 520 530 540
LELSNPNHPL LRKILTETPG TYHHSVMVAN LSEAACEAVG ANGLLARVGA YYHDLGKTKR
550 560 570 580 590 600
PQYFIENQMN IDNPHDKLSP QLSKNIIISH TTDGANMLRS YKFPKELVDI AEQHHGTSLL
610 620 630 640 650 660
KFFYYKAKEK GDQITEEEFR YPGPKPQSKE AAIISVADSV EAAVRSMHNP NPERIEKLVR
670 680 690 700 710
GIISDKLQDG QFSECDLTFK ELDTIAKTLC ATLKGIFHSR IEYPEATKKV K