P46312
PR
Gene name |
FAD6 |
Protein name |
Omega-6 fatty acid desaturase, chloroplastic |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G30950 |
EC number |
1.14.19.23: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P46312
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P46312-F1 | Predicted | AlphaFoldDB |
19 variants for P46312
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12326524 | 18 | C>R | No | 1000Genomes | |
| ENSVATH12326523 | 22 | V>G | No | 1000Genomes | |
| ENSVATH06805505 | 27 | A>V | No | 1000Genomes | |
| ENSVATH12326522 | 32 | V>F | No | 1000Genomes | |
| tmp_4_15059445_C_G | 35 | G>R | No | 1000Genomes | |
| ENSVATH12326515 | 39 | V>M | No | 1000Genomes | |
| ENSVATH02945957 | 40 | K>R | No | 1000Genomes | |
| ENSVATH14318275 | 48 | G>R | No | 1000Genomes | |
| ENSVATH02945955 | 51 | H>Q | No | 1000Genomes | |
| ENSVATH02945956 | 51 | H>R | No | 1000Genomes | |
| ENSVATH06805495 | 64 | I>N | No | 1000Genomes | |
| ENSVATH14318264 | 90 | E>G | No | 1000Genomes | |
| tmp_4_15058785_G_A | 138 | T>I | No | 1000Genomes | |
| tmp_4_15058777_G_T | 141 | L>I | No | 1000Genomes | |
| tmp_4_15058337_C_T | 236 | V>M | No | 1000Genomes | |
| tmp_4_15058083_C_G | 288 | V>L | No | 1000Genomes | |
| tmp_4_15057426_G_A | 400 | T>I | No | 1000Genomes | |
| tmp_4_15057333_T_C | 431 | E>G | No | 1000Genomes | |
| ENSVATH06805485 | 446 | Y>N | No | 1000Genomes |
No associated diseases with P46312
1 regional properties for P46312
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Histone H2A/H2B/H3 | 1 - 132 | IPR007125 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.19.23 | With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| chloroplast inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity | Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. |
| 1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity | Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. |
| 1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity | Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. |
| 1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity | Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. |
| 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity | Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. |
| 1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity | Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. |
| 1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity | Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. |
| 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming) | Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. |
| protein domain specific binding | Binding to a specific domain of a protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| photoinhibition | The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II. |
| unsaturated fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48628 | Omega-6 fatty acid desaturase, chloroplastic | Glycine max (Soybean) (Glycine hispida) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASRIADSLF | AFTGPQQCLP | RVPKLAASSA | RVSPGVYAVK | PIDLLLKGRT | HRSRRCVAPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRRIGCIKAV | AAPVAPPSAD | SAEDREQLAE | SYGFRQIGED | LPENVTLKDI | MDTLPKEVFE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IDDLKALKSV | LISVTSYTLG | LFMIAKSPWY | LLPLAWAWTG | TAITGFFVIG | HDCAHKSFSK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKLVEDIVGT | LAFLPLVYPY | EPWRFKHDRH | HAKTNMLVHD | TAWQPVPPEE | FESSPVMRKA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IIFGYGPIRP | WLSIAHWVNW | HFNLKKFRAS | EVNRVKISLA | CVFAFMAVGW | PLIVYKVGIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GWVKFWLMPW | LGYHFWMSTF | TMVHHTAPHI | PFKPADEWNA | AQAQLNGTVH | CDYPSWIEIL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CHDINVHIPH | HISPRIPSYN | LRAAHESIQE | NWGKYTNLAT | WNWRLMKTIM | TVCHVYDKEE |
| 430 | 440 | ||||
| NYIPFDRLAP | EESQPITFLK | KAMPNYTA |