P46069
Gene name |
PTGER3 |
Protein name |
Prostaglandin E2 receptor EP3 subtype |
Names |
PGE receptor EP3 subtype, PGE2 receptor EP3 subtype, Prostanoid EP3 receptor |
Species |
Oryctolagus cuniculus (Rabbit) |
KEGG Pathway |
ocu:100009389 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P46069
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P46069-F1 | Predicted | AlphaFoldDB |
1 variants for P46069
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 243 | T>A | No |
No associated diseases with P46069
1 regional properties for P46069
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 61 - 342 | IPR017452 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| prostaglandin E receptor activity | Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKETRGDGGS | APFCTRLNHS | YPGMWAPEAR | GNLTRPPGPG | EDCGSVSVAF | PITMLITGFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GNALAMLLVS | RSYRRRESKR | KKSFLLCIGW | LALTDLVGQL | LTSPVVILVY | LSKQRWEQLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSGRLCTFFG | LTMTVFGLSS | LFIASAMAVE | RALAIRAPHW | YASHMKTRAT | RAVLLGVWLA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLAFALLPVL | GVGQYTIQWP | GTWCFISTGR | GDNGTSSSHN | WGNLFFASTF | AFLGLLALAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TFTCNLATIK | ALVSRCRAKA | AASQSSAQWG | RITTETAIQL | MGIMCVLSVC | WSPLLIMMLK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MIFNQTSVEH | CKTDTGKQKE | CNFFLIAVRL | ASLNQILDPW | VYLLLRKILL | RKFCQVIHEN |
| 370 | 380 | 390 | 400 | 410 | |
| NEQKDEIQRE | NRNVSHSGQH | EEARDSEKSK | TIPGLFSILL | QADPGARPYQ | Q |