P45970
PR
Gene name |
lin-5 (T09A5.10) |
Protein name |
Spindle apparatus protein lin-5 |
Names |
Abnormal cell lineage protein 5 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_T09A5.10 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P45970
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P45970-F1 | Predicted | AlphaFoldDB |
No variants for P45970
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P45970 | |||||
No associated diseases with P45970
No regional properties for P45970
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P45970 | |||
Functions
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| condensed chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| kinetochore microtubule | Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. |
| microtubule organizing center | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| spindle midzone | The area in the center of the spindle where the spindle microtubules from opposite poles overlap. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| dynein complex binding | Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| establishment of meiotic spindle orientation | Any process that set the alignment of meiotic spindle relative to other cellular structures. |
| establishment of mitotic spindle localization | The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. |
| gonad development | The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. |
| locomotion | Self-propelled movement of a cell or organism from one location to another. |
| mitotic spindle elongation | The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| nuclear migration | The directed movement of the nucleus to a specific location within a cell. |
| regulation of G protein-coupled receptor signaling pathway | Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. |
| regulation of protein localization | Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. |
| reproduction | The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVSTSVVKS | MLQLTNYFGS | NFTPKTETIS | SLAELWERHG | SMIASMMSCD | TREFGTADKF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YEVIFRKIAT | TSLSFMTDSL | EPKLAASGDS | LEICKFYALF | LEYMRKDHSG | MLTRALEQAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SENRVDTAVL | LDMFLFFDNV | YSESTADDWW | ACLRRDDEDQ | EASSGFRTPK | RNNYSLTSLQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TPTATARRLR | TASSTARRSP | IAEAVDSPTM | KFMRSERELK | QSKARIFGLE | QMLGDLEDDK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TKLSAENRTL | KLSNSDLKSD | IAKLKGIAEE | AQFRAEELSC | DLEAKKDEVH | NILQQLNESR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MTLRSEQRSL | EEADIKKENL | TAKLKTVTED | NGKLMKQARE | LRDLNDYEFA | RFRQQEQELT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ETLRATQDQM | ADLQEQLTGV | EKIRASLKSE | NESLSASVEE | LSVASLRNKQ | DADNSKTMLS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EELARFEETV | DKLRQEKLEA | LSMANSRIDA | LRLEHSEREK | MMKSTNARLQ | ADLDEERNEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KRLMNLWNEL | NEKSLNVDKA | VHKSNEEFQS | MGSCLQNAKR | QIEQLEVACK | SKDDIIKFQE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EQNKRAANLI | KNEKAIRDQA | SAQFAEKLAI | LKNSLAEKEN | ETVTLKENFA | SVVMKHKAEL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EEKELFLQSR | VDLIQRLEHE | VADLREKESA | EIKKSTWMGE | RIKIFQQAPM | RGSRIRCGSP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DSLPDFLADN | GPTITEEELR | AQLATFPRKS | IAPSVDDNEF | DKGTPIGFKS | NMYDGRESIC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SLDFFDRSSL | QRSSMRSESI | QLASPSSAGE | FKQPFTPSGV | TKERVGVLTA | RNEKVKPHLK |
| 790 | 800 | 810 | 820 | ||
| CSYASEVGST | NSPSADEENI | KKSKKKNRRD | SIFSAFSSKK | Q |