P45780
Gene name |
epsF (VC_2731) |
Protein name |
Type II secretion system protein F |
Names |
T2SS protein F, Cholera toxin secretion protein EpsF, General secretion pathway protein F |
Species |
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
KEGG Pathway |
vch:VC_2731 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P45780
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2VMA | X-ray | 190 A | A/B | 56-170 | PDB |
| 2VMB | X-ray | 195 A | A/B | 56-170 | PDB |
| 3C1Q | X-ray | 170 A | A/B | 56-170 | PDB |
| AF-P45780-F1 | Predicted | AlphaFoldDB |
No variants for P45780
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P45780 | |||||
No associated diseases with P45780
3 regional properties for P45780
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | T2SS_GspF/T4SS_PilC conserved site | 166 - 194 | IPR001992 |
| domain | Type II secretion system protein GspF domain | 72 - 194 | IPR018076-1 |
| domain | Type II secretion system protein GspF domain | 274 - 396 | IPR018076-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| type II protein secretion system complex | A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein secretion by the type II secretion system | The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAFEYKALD | AKGRHKKGVI | EGDNARQVRQ | RLKEQSLVPM | EVVETQVKAA | RSRSQGFAFK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RGISTPDLAL | ITRQLATLVQ | SGMPLEECLR | AVAEQSEKPR | IRTMLVAVRA | KVTEGYTLSD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLGDYPHVFD | ELFRSMVAAG | EKSGHLDSVL | ERLADYAENR | QKMRSKLQQA | MIYPVVLVVF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVGIVAFLLA | AVVPKIVGQF | VQMGQALPAS | TQFLLDASDF | LQHWGISLLV | GLLMLIYLVR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WLLTKPDIRL | RWDRRVISLP | VIGKIARGLN | TARFARTLSI | CTSSAIPILD | GMRVAVDVMT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NQFVKQQVLA | AAENVREGSS | LRKALEQTKL | FPPMMLHMIA | SGEQSGELEG | MLTRAADNQD |
| 370 | 380 | 390 | 400 | ||
| NSFESTVNIA | LGIFTPALIA | LMAGMVLFIV | MATLMPILEM | NNLMSR |