P45684

PR
Gene name
rpoS
Protein name
RNA polymerase sigma factor RpoS
Names
Sigma S, Sigma-38
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA3622
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P45684

Entry ID Method Resolution Chain Position Source
7F0R EM 580 A F 1-334 PDB
7VF9 EM 404 A F 1-334 PDB
7XL3 EM 313 A F 1-334 PDB
7XL4 EM 386 A F 1-334 PDB
AF-P45684-F1 Predicted AlphaFoldDB

No variants for P45684

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P45684

No associated diseases with P45684

9 regional properties for P45684

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 123 - 136 IPR000943-1
domain RNA polymerase sigma-70 147 - 155 IPR000943-2
domain RNA polymerase sigma-70 271 - 283 IPR000943-3
domain RNA polymerase sigma-70 292 - 318 IPR000943-4
domain RNA polymerase sigma-70 region 3 179 - 253 IPR007624
domain RNA polymerase sigma-70 region 2 99 - 168 IPR007627
domain RNA polymerase sigma-70 region 4 267 - 320 IPR007630
domain RNA polymerase sigma-70 region 1.2 61 - 94 IPR009042
domain RNA polymerase sigma-70 like domain 96 - 322 IPR014284

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

9 GO annotations of biological process

Name Definition
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
negative regulation of secondary metabolite biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process.
positive regulation of chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of single-species biofilm formation on inanimate substrate Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
regulation of cell motility Any process that modulates the frequency, rate or extent of cell motility.
regulation of cellular response to heat Any process that modulates the frequency, rate or extent of cellular response to heat.
regulation of cellular response to oxidative stress Any process that modulates the frequency, rate or extent of cellular response to oxidative stress.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of response to salt stress Any process that modulates the frequency, rate or extent of response to salt stress.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALKKEGPEF DHDDEVLLLE PGIMLDESSA DEQPSPRATP KATTSFSSKQ HKHIDYTRAL
70 80 90 100 110 120
DATQLYLNEI GFSPLLTPEE EVHFARLAQK GDPAGRKRMI ESNLRLVVKI ARRYVNRGLS
130 140 150 160 170 180
LLDLIEEGNL GLIRAVEKFD PERGFRFSTY ATWWIRQTIE RAIMNQTRTI RLPIHVVKEL
190 200 210 220 230 240
NVYLRAAREL THKLDHEPSP EEIANLLEKP VAEVKRMLGL NERVTSVDVS LGPDSDKTLL
250 260 270 280 290 300
DTLTDDRPTD PCELLQDDDL SESIDQWLTE LTDKQREVVI RRFGLRGHES STLEEVGQEI
310 320 330
GLTRERVRQI QVEALKRLRE ILEKNGLSSD ALFQ