P45617

PR
Gene name
ptsI (MCAP_0233)
Protein name
Phosphoenolpyruvate-protein phosphotransferase
Names
Phosphotransferase system, enzyme I
Species
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
KEGG Pathway
mcp:MCAP_0233
EC number
2.7.3.9: Phosphotransferases with a nitrogenous group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

213-285 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P45617

Entry ID Method Resolution Chain Position Source
AF-P45617-F1 Predicted AlphaFoldDB

No variants for P45617

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P45617

No associated diseases with P45617

6 regional properties for P45617

Type Name Position InterPro Accession
domain PEP-utilising enzyme, C-terminal 252 - 541 IPR000121
domain Phosphotransferase system, enzyme I-like 5 - 566 IPR006318
domain PEP-utilising enzyme, mobile domain 153 - 226 IPR008279
domain Phosphotransferase system, enzyme I N-terminal 6 - 127 IPR008731
active_site PEP-utilising enzyme, active site 185 - 196 IPR018274
conserved_site PEP-utilising enzyme, conserved site 447 - 465 IPR023151

Functions

Description
EC Number 2.7.3.9 Phosphotransferases with a nitrogenous group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
metal ion binding Binding to a metal ion.
phosphoenolpyruvate-protein phosphotransferase activity Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.

2 GO annotations of biological process

Name Definition
phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKQIKGIAA SEGISLARAL VIKETKLDIQ KQLISDVDQE IIKLEQAIEK SIADLKKIQQ
70 80 90 100 110 120
ITLKKLGEEK AAIFDAHQDI ANDPAIKEEV VELIKKEKVN AEYALFTVSN NYFEMFSQLE
130 140 150 160 170 180
DPYFKERSAD IKDVSLRIIS HILGLEIHDL STIDKEVIII SDDLTPSQTA QLDKKFVKGF
190 200 210 220 230 240
LTNVGGRTSH AAIMARSLEI PAILGLKNIT ELVKTDDLIA LDGSSGIVEL DLNDDDIKNY
250 260 270 280 290 300
QTKVQQYIEL KEQLKKFKDE PSLTKDKIKK LIEANIGSTN DVQSVLDSGA EGIGLFRTEF
310 320 330 340 350 360
LYMDNDHFPT EEEQFEAYKK VVSQIKHLVV FRTLDIGGDK KLSYFKFDEE MNPFLGYRAI
370 380 390 400 410 420
RFTLDRKDIF KDQIRALLRA SAFGKLGIMF PMIATIDEFK QAKTFVEECK IELDKEGIKY
430 440 450 460 470 480
DNQVQIGMMV EIPSAAILAD QFAKYADFFS IGTNDLIQYS FASDRMNQNV SYLYQPLNPS
490 500 510 520 530 540
LLRLIQLTIS GAHKHNKWVG MCGEMAGDSK ALPILLGLDL DAFSMSATSV LKARSLMSKI
550 560 570
EFSKAKILAN KVLECETNEQ VNKLVEDFLN NLD