P45359

PR
Gene name
thlA (thl, CA_C2873)
Protein name
Acetyl-CoA acetyltransferase
Names
Acetoacetyl-CoA thiolase, CaTHL
Species
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
KEGG Pathway
cac:CA_C2873
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

142-221 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P45359

Entry ID Method Resolution Chain Position Source
4WYR X-ray 230 A A/B 1-392 PDB
4XL2 X-ray 177 A A/B 1-392 PDB
AF-P45359-F1 Predicted AlphaFoldDB

No variants for P45359

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P45359

No associated diseases with P45359

3 regional properties for P45359

Type Name Position InterPro Accession
domain MIF4G-like, type 3 31 - 243 IPR003890
domain MIF4G-like, type 1 349 - 473 IPR015172
domain MIF4G-like, type 2 488 - 770 IPR015174

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
acetyl-CoA C-acetyltransferase activity Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKEVVIASAV RTAIGSYGKS LKDVPAVDLG ATAIKEAVKK AGIKPEDVNE VILGNVLQAG
70 80 90 100 110 120
LGQNPARQAS FKAGLPVEIP AMTINKVCGS GLRTVSLAAQ IIKAGDADVI IAGGMENMSR
130 140 150 160 170 180
APYLANNARW GYRMGNAKFV DEMITDGLWD AFNDYHMGIT AENIAERWNI SREEQDEFAL
190 200 210 220 230 240
ASQKKAEEAI KSGQFKDEIV PVVIKGRKGE TVVDTDEHPR FGSTIEGLAK LKPAFKKDGT
250 260 270 280 290 300
VTAGNASGLN DCAAVLVIMS AEKAKELGVK PLAKIVSYGS AGVDPAIMGY GPFYATKAAI
310 320 330 340 350 360
EKAGWTVDEL DLIESNEAFA AQSLAVAKDL KFDMNKVNVN GGAIALGHPI GASGARILVT
370 380 390
LVHAMQKRDA KKGLATLCIG GGQGTAILLE KC