P45331
Gene name |
metE |
Protein name |
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase |
Names |
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme |
Species |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
KEGG Pathway |
hin:HI_1702 |
EC number |
2.1.1.14: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P45331
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P45331-F1 | Predicted | AlphaFoldDB |
No variants for P45331
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P45331 | |||||
No associated diseases with P45331
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.14 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity | Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methionine biosynthetic process | The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTTSHILGFP | RVGAKRELKF | AQERYWRKEL | AEQDLLDLAK | ALREKNWKHQ | AAANADFVAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GDFTFYDHIL | DLQVATGAIP | ARFGFDSQNL | TLDQYFQLAR | GNKDQFAIEM | TKWFDTNYHY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVPEFQKSTA | FKANPAHYVN | QIREAKALGL | NFKPVIVGPL | TFLWLGKEKG | EAFNRFDLLN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QLVPVYVEIL | NALVAEGAEW | IQIDEPALAL | DLPAEWVEAY | KSVYTELSKV | NAKLLLATYF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GSVAEHAELL | KALPVAGLHL | DLVRAPEQLA | AFEDYSKVLS | AGVIEGRNIW | RANLNKVLDV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEPLKAKLGE | RLWIAPSCSL | LHTPFDLEVE | VQLKEKNTAL | YSWLSFTLQK | VEELNVLKQA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LNNGRASVQA | ALDASQVAAD | ARATSKEIHR | PEVAERLANL | PKGADQRKSP | FAERIVKQNA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WLNLPLLPTT | NIGSFPQTTE | IRHARASFKK | GELSLADYEA | AMKKEIEYVV | RRQEELDLDV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LVHGEAERND | MVEYFGELLD | GFAFTKFGWV | QSYGSRCVKP | PVIYGDVTRP | EPMTVRWSQY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AQSLTNRVMK | GMLTGPVTIL | QWSFVRNDIP | RSTVCKQIGV | ALSDEVLDLE | AAGIKVIQID |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EPAIREGLPL | KRADWDAYLQ | WAGEAFRLSS | MGVQDDTQIH | THMCYSEFND | ILPAIAALDA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DVITIETSRS | DMELLTAFAD | FKYPNDIGPG | VYDIHSPRVP | TATEVEHLLR | KALNVIPKER |
| 730 | 740 | 750 | |||
| LWVNPDCGLK | TRGWTETIDQ | LKVMVDVTKK | LRAELA |