P45215

PR
Gene name
HI_1459
Protein name
Probable RNA polymerase sigma factor HI_1459
Names
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_1459
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P45215

Entry ID Method Resolution Chain Position Source
AF-P45215-F1 Predicted AlphaFoldDB

No variants for P45215

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P45215

No associated diseases with P45215

4 regional properties for P45215

Type Name Position InterPro Accession
conserved_site RNA polymerase sigma factor 70, ECF, conserved site 43 - 74 IPR000838
domain RNA polymerase sigma-70 region 2 27 - 88 IPR007627
domain RNA polymerase sigma factor 70, region 4 type 2 136 - 186 IPR013249
domain RNA polymerase sigma-70 like domain 32 - 190 IPR014284

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

2 GO annotations of biological process

Name Definition
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFISYISFK GIKMNVISDL ELQQIRTQML TFAQLQVNQA DLAEDLVQEA FLSAFKNLAN
70 80 90 100 110 120
FKRQSAFKTW IFAILKNKII DYLRQKGRFV LESELEDENT NNSFFDEKGH WKPEYHPSEL
130 140 150 160 170 180
QGEEETVYSD EFWLIFETCL NCLPAKQAKI FMMREFLELS SEEICQETHL TSSNLHTTLY
190
RARLQLQNCL SKKL