P45119
Gene name |
aceE (HI_1233) |
Protein name |
Pyruvate dehydrogenase E1 component |
Names |
PDH E1 component |
Species |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
KEGG Pathway |
hin:HI_1233 |
EC number |
1.2.4.1: With a disulfide as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P45119
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P45119-F1 | Predicted | AlphaFoldDB |
No variants for P45119
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P45119 | |||||
No associated diseases with P45119
Functions
| Description | ||
|---|---|---|
| EC Number | 1.2.4.1 | With a disulfide as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| pyruvate dehydrogenase (acetyl-transferring) activity | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glycolytic process | The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEILKNDVD | PIETQDWLQS | LDSLIREEGV | ERAQYIVEQV | IGQARTSGVS | LPTGVTTDYV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NTIPVAEQPA | YPGDHAIERR | IRSAVRWNAI | AMVLRSQKKD | LDLGGHISTF | QSAATMYEVC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YNHFFKAATE | KNGGDLIFFQ | GHAAPGMYAR | AFLEGRLTEE | QMDNFRQEAF | TDGLSSYPHP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLMPEFWQFS | TVSMGLGPVN | AIYQARFLKY | LDNRGLKDTK | DQKVYAFLGD | GEMDEIESKG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALTFAAREHL | DNLIFTISCN | LQRLDGPVNG | NGKIVQELEG | LFTGAGWEVI | KVLWGSDWDK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFAKDTSGKL | TQLMMEVVDG | DYLTFKSKDG | AYIREHFFGR | YPETAALVAD | MTDDEIWALR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RGAHDSEKLY | AAYAKAQNAT | KPVVILAHQV | KGYKIPEAES | KNTAHQSKKM | SYESLKGFRD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FFELPLTDEQ | VEKLEYIKFA | EGTPEYEYLH | GHRKALNGYV | PARRTKFDVE | YKVPALEEFK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ALLEEQPRGI | STTMAFTRAL | NILLKDKNIG | KTIVPMIADE | ARTFGMEGLF | RQVGIYNPHG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QNYIPSDRDL | VAYYREAKDG | QVLQEGINEL | GATASWLAAA | NSYSVNNQPM | IPFFIYYSMF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GFQRVGDMMW | AAGDQLARGF | MVGGTSGRTT | LNGEGLQHED | GHSHIQAGII | PNCITYDPSF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AFEVAVIMQD | GINRMYGEKQ | EDVFYYMTTL | NEVMDQPAMP | AGAEEGIRKG | LYKFETVEGK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KGKGHVQLLG | SGAIMRHVRE | AAQILANDYG | VTSDVFSAPS | FNELAREGHD | AARWNLLHPT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ETQRVPYVAQ | VLADLPTVAS | TDYVKGYADQ | IRAFVPSKHY | HVLGTDGFGR | SDSRANLREH |
| 850 | 860 | 870 | 880 | ||
| FEVDARYVVV | AALSQLAKEG | TVSNQVVADA | IAKFGLNVDR | INPLYA |