P45118

PR
Gene name
aceF (HI_1232)
Protein name
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Names
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_1232
EC number
2.3.1.12: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

168-344 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P45118

Entry ID Method Resolution Chain Position Source
AF-P45118-F1 Predicted AlphaFoldDB

No variants for P45118

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P45118

No associated diseases with P45118

6 regional properties for P45118

Type Name Position InterPro Accession
domain Biotin/lipoyl attachment 2 - 75 IPR000089-1
domain Biotin/lipoyl attachment 108 - 181 IPR000089-2
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 336 - 566 IPR001078
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 25 - 54 IPR003016-1
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 131 - 160 IPR003016-2
domain Peripheral subunit-binding domain 258 - 295 IPR004167

Functions

Description
EC Number 2.3.1.12 Transferring groups other than amino-acyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).

3 GO annotations of molecular function

Name Definition
acetyltransferase activity Catalysis of the transfer of an acetyl group to an acceptor molecule.
dihydrolipoyllysine-residue acetyltransferase activity Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.
lipoic acid binding Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid.

2 GO annotations of biological process

Name Definition
acetyl-CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKQIQIPDI GSDEVTVTEV MVNVGDTISV DQSIINVEGD KASMEVPAPE AGVVKEILVK
70 80 90 100 110 120
VGDKVSTGTP MLVLEAAGAA PAADEPTAPV ADAPTAPVVA TAPTASAIVE VNVPDIGGDE
130 140 150 160 170 180
VNVTEIMVAV GDTITEEQSL ITVEGDKASM EVPAPFGGVV KEILVKSGDK VSTGSLIMRF
190 200 210 220 230 240
EVLGAAPAES ASAPASTSAP QTAAPATTAQ APQAAAPDTT AQAPQAAAPD TTAQAAQSNN
250 260 270 280 290 300
NVSGLSQEQV EASTGYAHAT PVIRRLAREF GVNLDKVKGT GRKGRIVKED IEAYVKTAVK
310 320 330 340 350 360
AYESGATAQA TGNGVANGAG LGLLPWPKVD FSKFGEIEEV ELSRINKISG ANLHRNWVII
370 380 390 400 410 420
PHVTHFDKAD ITDLEAFRKE QNALREKQKL GVKITPVVFI MKAVAKALEA YPRFNSSITE
430 440 450 460 470 480
DAQRLILKKY INIGVAVDTP NGLVVPVFKN VNKKGIIELS RELMEVSKKA REGKLTASDM
490 500 510 520 530 540
QGGCFTISSL GGIGTTHFAP IVNAPEVAIL GVSKSSMEPV WNGKEFAPRL ILPMSLSFDH
550 560
RVIDGADGAR FISYLGSVLA DLRRLVM