P44804

PR
Gene name
rep
Protein name
ATP-dependent DNA helicase Rep
Names
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_0649
EC number
5.6.2.4: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

610-670 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P44804

Entry ID Method Resolution Chain Position Source
AF-P44804-F1 Predicted AlphaFoldDB

No variants for P44804

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P44804

No associated diseases with P44804

2 regional properties for P44804

Type Name Position InterPro Accession
domain UvrD-like helicase, ATP-binding domain 1 - 280 IPR014016
domain UvrD-like DNA helicase, C-terminal 271 - 614 IPR014017

Functions

Description
EC Number 5.6.2.4 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
3'-5' DNA helicase activity Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
single-stranded DNA binding Binding to single-stranded DNA.

2 GO annotations of biological process

Name Definition
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
recombinational repair A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLNPQQQQA VEYVTGPCLV LAGAGSGKTR VIINKIAHLI EKCGYSPKQI AAVTFTNKAA
70 80 90 100 110 120
REMKERVAHS IGKEQSKGLL VSTFHTLGFD ILKREYKALG FKSNMTLFDE HDQFALLKEL
130 140 150 160 170 180
TADVLKEDKD LLRELISVIS NWKNDLISPK QAFALARDAK YQTFAKCYER YATQIRTYNA
190 200 210 220 230 240
LDFDDLIMLP TLLFKQNEEV RSKWQAKIRY LLVDEYQDTN TSQYELIKLL VGDRACFTVV
250 260 270 280 290 300
GDDDQSIYSW RGARPENMVR LRDDFPRLNV IKLEQNYRST QRILHCANIL IDNNEHVFDK
310 320 330 340 350 360
KLFSTIGKGE KLLVIEAKNE EHEAERIVAE LIAHRFSRKT KYKDYAILYR GNHQSRLLEK
370 380 390 400 410 420
VLMQNRIPYK ISGGTSFFSR AEIKDMMAYL RLVVNQDDDA AFLRIVNTPK REIGTATLQK
430 440 450 460 470 480
LGELAQEKHI SLFEAIFEFE LIQRITPKAY DSLQKFGRWI VELNDEIQRS EPERAVRSML
490 500 510 520 530 540
SAIHYEEYLY EYATSPKAAE MQSKNVATLF DWVADMLKGD ETNEPMNLNQ VVTRLTLRDM
550 560 570 580 590 600
LERGEDDDDS DQVQLMTLHA SKGLEFPYVY LIGMEEGILP HQTSIDEDNV EEERRLAYVG
610 620 630 640 650 660
ITRAQKELTF SLCRERRQYG ELVRPEPSRF LAELPNDDVL WERDKPKLTT EQKQEKTQNQ
LDRLRAILKS