P44798

PR
Gene name
torZ (bisC, HI_0643)
Protein name
Trimethylamine-N-oxide reductase
Names
TMAO reductase, Trimethylamine oxidase
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_0643
EC number
1.7.2.3: With a cytochrome as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-144 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P44798

Entry ID Method Resolution Chain Position Source
7L5I X-ray 173 A A 41-825 PDB
7L5S X-ray 209 A A 41-825 PDB
AF-P44798-F1 Predicted AlphaFoldDB

No variants for P44798

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P44798

No associated diseases with P44798

7 regional properties for P44798

Type Name Position InterPro Accession
conserved_site Twin-arginine translocation pathway, signal sequence 1 - 40 IPR006311
conserved_site Molybdopterin oxidoreductase, prokaryotic, conserved site 504 - 521 IPR006655-1
conserved_site Molybdopterin oxidoreductase, prokaryotic, conserved site 719 - 746 IPR006655-2
domain Molybdopterin oxidoreductase 94 - 562 IPR006656
domain Molybdopterin dinucleotide-binding domain 680 - 801 IPR006657
domain Molybdopterin oxidoreductase, N-terminal 50 - 90 IPR041460
domain Trimethylamine-N-oxide reductase-like, molybdopterin-binding domain 678 - 807 IPR041954

Functions

Description
EC Number 1.7.2.3 With a cytochrome as acceptor
Subcellular Localization
  • Periplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.

4 GO annotations of molecular function

Name Definition
electron transfer activity Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
molybdenum ion binding Binding to a molybdenum ion (Mo).
molybdopterin cofactor binding Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
trimethylamine-N-oxide reductase (cytochrome c) activity Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+.

1 GO annotations of biological process

Name Definition
anaerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKNNVNEQR RDFLKKTSLG VAGSALSGGM VGVVSKSAVA KEAEMKTVVT AAHWGSIGVV
70 80 90 100 110 120
VQDGKVVKSG PAIEPAVPNE LQTVVADQLY SERRVKCPMV RKGFLANPGK SDTTMRGRDE
130 140 150 160 170 180
WVRVSWDEAL DLVHNQLKRV RDEHGSTGIF AGSYGWFSCG SLHASRTLLQ RYMNATGGFV
190 200 210 220 230 240
GHKGDYSTGA AQVIMPHVLG TIEVYEQQTS WESILESSDI IVLWSANPLT TMRIAWMSTD
250 260 270 280 290 300
QKGIEYFKKF QASGKRIICI DPQKSETCQM LNAEWIPVNT ATDVPLMLGI AHTLVEQGKH
310 320 330 340 350 360
DKDFLKKYTS GYAKFEEYLL GKTDGQPKTA EWAAKICGVP AETIKQLAAD FASKRTMLMG
370 380 390 400 410 420
GWGMQRQRHG EQTHWMLVTL ASMLGQIGLP GGGFGLSYHY SNGGVPTATG GIIGSITASP
430 440 450 460 470 480
SGKAGAKTWL DDTSKSAFPL ARIADVLLHP GKKIQYNGTE ITYPDIKAVY WAGGNPFVHH
490 500 510 520 530 540
QDTNTLVKAF QKPDVVIVNE VNWTPTARMA DIVLPATTSY ERNDLTMAGD YSMMSVYPMK
550 560 570 580 590 600
QVVPPQFEAK NDYDIFVELA KRAGVEEQYT EGKTEMEWLE EFYNAAFSAA RANRVAMPRF
610 620 630 640 650 660
DKFWAENKPL SFEAGEAAKK WVRYGEFRED PLLNPLGTPS GKIEIFSDVV EKMNYNDCKG
670 680 690 700 710 720
HPSWMEPEEF AGNVTEEYPL ALVTPHPYYR LHSQLAHTSL RQKYAVNDRE PVMIHPEDAA
730 740 750 760 770 780
ARGIKDGDIV RIHSKRGQVL AGAAVTENII KGTVALHEGA WYDPMYLGES EKPLCKNGCA
790 800 810 820
NVLTRDEGTS KLAQGNSPNT CIVQIEKFIG VAPEVTVFKQ PKQVA