P44749

PR
Gene name
rsmA
Protein name
Ribosomal RNA small subunit methyltransferase A
Names
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_0549
EC number
2.1.1.182: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

242-287 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P44749

Entry ID Method Resolution Chain Position Source
AF-P44749-F1 Predicted AlphaFoldDB

No variants for P44749

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P44749

No associated diseases with P44749

2 regional properties for P44749

Type Name Position InterPro Accession
conserved_site Ribosomal RNA adenine methylase transferase, conserved site 41 - 68 IPR020596
domain Ribosomal RNA adenine methylase transferase, N-terminal 25 - 203 IPR020598

Functions

Description
EC Number 2.1.1.182 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.
RNA binding Binding to an RNA molecule or a portion thereof.
rRNA (adenine-N6,N6-)-dimethyltransferase activity Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.

1 GO annotations of biological process

Name Definition
rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNSKKHLGHT ARKRFGQNFL HDTSVIQGIV AAIYPQPNQF LVEIGPGLGA LTEPVGELVD
70 80 90 100 110 120
HLTVVELDRD LAERLRHHPF LHQKLTVIET DAMQFDFGAL YTKENLAEKG QKLRVFGNLP
130 140 150 160 170 180
YNISTPLMFH LFKYHDVIQD MHFMLQKEVV KRLCAAPNSK AYGRLTIMAQ YFCQVMPVLE
190 200 210 220 230 240
VPPSAFKPAP KVDSAVVRLI PHKELPHPVK DLYWLNRVCS QAFNQRRKTL RNALSTLFSP
250 260 270 280
ENLTALGIDL NARAENLAIA DYARLANWLA DNPPADVNKD EILDSEE