P44704
Gene name |
pssA (HI_0425) |
Protein name |
CDP-diacylglycerol--serine O-phosphatidyltransferase |
Names |
Phosphatidylserine synthase |
Species |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
KEGG Pathway |
hin:HI_0425 |
EC number |
2.7.8.8: Transferases for other substituted phosphate groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P44704
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3HSI | X-ray | 220 A | A/B/C | 1-455 | PDB |
| AF-P44704-F1 | Predicted | AlphaFoldDB |
No variants for P44704
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P44704 | |||||
No associated diseases with P44704
3 regional properties for P44704
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phospholipase D/Transphosphatidylase | 134 - 160 | IPR001736-1 |
| domain | Phospholipase D/Transphosphatidylase | 356 - 383 | IPR001736-2 |
| domain | Phospholipase D-like domain | 263 - 408 | IPR025202 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.8.8 | Transferases for other substituted phosphate groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity | Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+). |
| CDP-diacylglycerol-serine O-phosphatidyltransferase activity | Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiolipin biosynthetic process | The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLINKTKRAE | QNLNNLPFLA | LQAEQIEFLG | SSAEFKTQII | ELIRNAKKRI | YVTALYWQKD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EAGQEILDEI | YRVKQENPHL | DVKVLIDWHR | AQRNLLGAEK | SATNADWYCE | QRQTYQLPDD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PNMFFGVPIN | TREVFGVLHV | KGFVFDDTVL | YSGASINNVY | LHQFEKYRYD | RYQKITHAEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ADSMVNFIND | YLLDFSAVYP | LDVTNRPRTK | EIRGNIRAYR | KDLAQNGEYS | LKSAVKLPNV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSVSPLFGLG | ASGNELNQVI | EDLFLQVQKK | LVICTPYFNF | PRTLQHKIAT | LLENGKRVEI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IVGDKVANDF | YIPPEQPFKM | AGALPYLYES | NLRRFCEKFE | TQIESGQLVV | RLWRDGDNTY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HLKGVWVDDR | YILLTGNNLN | PRAWRLDAEN | GLLIYDPQQQ | LLAQVEKEQN | QIRQHTKVLK |
| 430 | 440 | 450 | |||
| HYTELEELNQ | YPEPVQKLLK | KFARIKADKL | VKMIL |