P44578

PR
Gene name
arcB (HI_0220)
Protein name
Aerobic respiration control sensor protein ArcB homolog
Names
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

56-146 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P44578

Entry ID Method Resolution Chain Position Source
AF-P44578-F1 Predicted AlphaFoldDB

No variants for P44578

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P44578

No associated diseases with P44578

7 regional properties for P44578

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 233 - 321 IPR003594
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 119 - 186 IPR003661
domain Signal transduction histidine kinase-related protein, C-terminal 269 - 283 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 287 - 297 IPR004358-2
domain Signal transduction histidine kinase-related protein, C-terminal 303 - 321 IPR004358-3
domain Histidine kinase domain 128 - 325 IPR005467
domain Histidine kinase receptor ArcB, transmembrane domain 15 - 88 IPR040642

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKNFKYFAQS YVDWVIRLGR LRFSLLGVMI LAVLALCTQI LFSLFIVHQI SWVDIFRSVT
70 80 90 100 110 120
FGLLTAPFVI YFFTLLVEKL EHSRLDLSSS VNRLENEVAE RIAAQKKLSQ ALEKLEKNSR
130 140 150 160 170 180
DKSTLLATIS HEFRTPLNGI VGLSQILLDD ELDDLQRNYL KTINISAVSL GYIFSDIIDL
190 200 210 220 230 240
EKIDASRIEL NRQPTDFPAL LNDIYNFASF LAKEKNLIFS LELEPNLPNW LNLDRVRLSQ
250 260 270 280 290 300
ILWNLISNAV KFTDQGNIIL KIMRNQDCYH FIVKDTGMGI SPEEQKHIFE MYYQVKESRQ
310 320
QSAGSGIGLA ISKNLAQLMG RGFNS