P44423

PR
Gene name
hisC1 (hisC, HI_0470)
Protein name
Histidinol-phosphate aminotransferase 1
Names
Imidazole acetol-phosphate transaminase 1
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_0470
EC number
2.6.1.9: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P44423

Entry ID Method Resolution Chain Position Source
AF-P44423-F1 Predicted AlphaFoldDB

No variants for P44423

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P44423

No associated diseases with P44423

2 regional properties for P44423

Type Name Position InterPro Accession
binding_site Aminotransferase, class-II, pyridoxal-phosphate binding site 223 - 232 IPR001917
domain Aminotransferase, class I/classII 44 - 363 IPR004839

Functions

Description
EC Number 2.6.1.9 Transaminases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
histidinol-phosphate transaminase activity Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

1 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNDYNSHILQ WKKTIMTITT LSRQNIQALT PYQSARKLGG NGTIWLNANE YPTSPEFQLS
70 80 90 100 110 120
GKDLNRYPEP QPQRVVQAYA NYAGVSTENV LVTRGGDEGI ELIIHTFCEP KQDAILFCPP
130 140 150 160 170 180
TYGMYAVSAE TAGVLSKTVP LTDDFQLNLP EIKNHLNDVK VVFVCSPNNP TGNLLKQSDI
190 200 210 220 230 240
LDLLQITAGK AIVVVDEAYI EFCPEASVIN LLKNYPHLAI IRTLSKAFAL AGLRCGFVLA
250 260 270 280 290 300
NPELIDILSK VIAPYPIPVP SADLAEQALR PSNIATVQAL TQELLSNRQW LAKALLVLHQ
310 320 330 340 350 360
VEKVYESEAN YLLIKCQNGQ AVFKALWEQG IILRDQNKTL HLQNCIRITV GTRNECEKVV
EAIKEVK