P44323

PR
Gene name
infB (HI_1284)
Protein name
Translation initiation factor IF-2
Names
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_1284
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-273 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P44323

Entry ID Method Resolution Chain Position Source
AF-P44323-F1 Predicted AlphaFoldDB

No variants for P44323

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P44323

No associated diseases with P44323

6 regional properties for P44323

Type Name Position InterPro Accession
domain Translational (tr)-type GTP-binding domain 328 - 498 IPR000795
domain Small GTP-binding protein domain 331 - 488 IPR005225
domain Translation initiation factor IF-2, N-terminal 253 - 303 IPR006847
domain Initiation factor 2 associated domain, bacterial 10 - 45 IPR013575
domain Translation initiation factor IF- 2, domain 3 605 - 719 IPR023115
domain Translation initiation factor IF-2, domain II 505 - 598 IPR044145

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEDVKADAP KKLSIQRRTK TTVSSTTTGG KSKEVQVEVR KKRTVKTDIA QQEEAKLKAQ
70 80 90 100 110 120
QEAEAKKIAE QKAAEEKARL EAEKAKAETA KPVKSAVDSK AKSVESEKEK RKAGEAELRR
130 140 150 160 170 180
KAEELARQKA EEQARRAVEE AKRYAEADDS DNESSSEDYS DYNLSSRYAL EAEDEEDRRN
190 200 210 220 230 240
ENRGRGKNKV AKAKKGGRDD ENSKNSKNER ESNRKNQKDA KFGKGKNGKK GAALQQAFTK
250 260 270 280 290 300
PAQVVKSDVV IGETITVAEL ANKMAVKATE IIKMMMKMGE MVTINQVIDQ ETAQLVAEEL
310 320 330 340 350 360
GHKVILRNEN ELEEAVLGDR DVNAEKVTRA PVVTIMGHVD HGKTSLLDYI RKAKVAAGEA
370 380 390 400 410 420
GGITQHIGAY HVEMDDGKMI TFLDTPGHAA FTSMRARGAK ATDIVVLVVA ADDGVMPQTI
430 440 450 460 470 480
EAIQHAKAAG APLVVAVNKI DKPEANLDRV EQELLQHDVI SEKFGGDVQF VPVSAKKGTG
490 500 510 520 530 540
VDDLLDAILL QSEVLELTAV KDGMASGVVI ESYLDKGRGP VATILVQSGT LRKGDIVLCG
550 560 570 580 590 600
FEYGRVRAMR DENGKEVDEA GPSIPVELLG LSGVPAAGDE ATVVRDEKKA REVALYRQGK
610 620 630 640 650 660
FREVKLARQQ KAKLENMFSN MSEGDVAELN VIVKADVQGS VEAIVQALNE LSTNEVKVKV
670 680 690 700 710 720
VGSGVGGITE TDATLATASN AIIVGFNVRA DATARRVIEA ENIDLRYYSI IYELLNEIKA
730 740 750 760 770 780
AMSGMLEPEF KQEIIGLAEV RDVFRHPKFG AIAGCMVTEG VVKRNNPIRV LRDNVVIFEG
790 800 810 820
ELESLRRFKD DVSEVRNGME CGIGVKNYND VKVGDQIEVF EVVEVKRSI