P44308

PR
Gene name
nadR (HI_0763)
Protein name
Bifunctional NAD biosynthesis protein NadR
Names
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_0763
EC number
2.7.1.22: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

324-421 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P44308

Entry ID Method Resolution Chain Position Source
1LW7 X-ray 290 A A 57-421 PDB
AF-P44308-F1 Predicted AlphaFoldDB

No variants for P44308

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P44308

No associated diseases with P44308

4 regional properties for P44308

Type Name Position InterPro Accession
domain Cytidyltransferase-like domain 60 - 130 IPR004821
domain Nicotinamide-nucleotide adenylyltransferase 58 - 390 IPR006417
domain NadR/Ttd14, AAA domain 229 - 389 IPR038727
domain NadR, nicotinamide/nicotinate mononucleotide adenylyltransferase domain 60 - 222 IPR041749

Functions

Description
EC Number 2.7.1.22 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Cytoplasm
  • Found as a soluble cytoplasmic protein as well as a membrane-associated protein
  • In combination with corepressor (NAD), the cytoplasmic form of NadR would be capable of acting as a transcriptional repressor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
nicotinamide-nucleotide adenylyltransferase activity Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.
ribosylnicotinamide kinase activity Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide.

2 GO annotations of biological process

Name Definition
NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGFTTGREFH PALRMRAKYN AKYLGTKSER EKYFHLAYNK HTQFLRYQEQ IMSKTKEKKV
70 80 90 100 110 120
GVIFGKFYPV HTGHINMIYE AFSKVDELHV IVCSDTVRDL KLFYDSKMKR MPTVQDRLRW
130 140 150 160 170 180
MQQIFKYQKN QIFIHHLVED GIPSYPNGWQ SWSEAVKTLF HEKHFEPSIV FSSEPQDKAP
190 200 210 220 230 240
YEKYLGLEVS LVDPDRTFFN VSATKIRTTP FQYWKFIPKE ARPFFAKTVA ILGGESSGKS
250 260 270 280 290 300
VLVNKLAAVF NTTSAWEYGR EFVFEKLGGD EQAMQYSDYP QMALGHQRYI DYAVRHSHKI
310 320 330 340 350 360
AFIDTDFITT QAFCIQYEGK AHPFLDSMIK EYPFDVTILL KNNTEWVDDG LRSLGSQKQR
370 380 390 400 410 420
QQFQQLLKKL LDKYKVPYIE IESPSYLDRY NQVKAVIEKV LNEEEISELQ NTTFPIKGTS
Q