P44039

PR
Gene name
truD
Protein name
tRNA pseudouridine synthase D
Names
tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_0701
EC number
5.4.99.27: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

252-325 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P44039

Entry ID Method Resolution Chain Position Source
AF-P44039-F1 Predicted AlphaFoldDB

No variants for P44039

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P44039

No associated diseases with P44039

2 regional properties for P44039

Type Name Position InterPro Accession
domain Pseudouridine synthase, TruD, insertion domain 155 - 311 IPR011760
conserved_site Pseudouridine synthase TruD, conserved site 77 - 90 IPR020119

Functions

Description
EC Number 5.4.99.27 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
RNA binding Binding to an RNA molecule or a portion thereof.
tRNA pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

2 GO annotations of biological process

Name Definition
pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs.
tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLEQLPYLAL KTPPKTTALL KAECADFIVK EHLGYEMSGD GEFVALYVRK TDCNTLFVGE
70 80 90 100 110 120
KLAKFAGVSE RNMGYAGLKD RRAVTEQWFC LQMPGMETPD FSQFELDGVE ILTVTRHNRK
130 140 150 160 170 180
IRTGSLEGNY FDILLRGAEE SDELKARLDF VANFGFPNYF TEQRFGRDGH NLTQALRWAQ
190 200 210 220 230 240
GEIKVKDRKK RSFYLSAARS EIFNLVVAAR IEKSTINQVL PNDIVQLAGS HSWFKADEKE
250 260 270 280 290 300
DLTALQVRLE NQDILLTAPL IGEDILAASE IENEIVNQHS AFDPLMKQER MKAARRPLLM
310 320 330
KAKGFSWAFE PEGLRLKFYL PAGSYATALV RELVNYTEE