P43825

PR
Gene name
lysS (lysU, HI_1211)
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG Pathway
hin:HI_1211
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P43825

Entry ID Method Resolution Chain Position Source
AF-P43825-F1 Predicted AlphaFoldDB

No variants for P43825

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P43825

No associated diseases with P43825

2 regional properties for P43825

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 26 - 35 IPR001412
domain Aminoacyl-tRNA synthetase, class I, anticodon-binding 422 - 504 IPR045462

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
magnesium ion binding Binding to a magnesium (Mg) ion.
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEQEVKELD LNGEMLVRRE KLAALRAKGN AFPNKFRRDA LAQDLHNQYD AEDGEILKEK
70 80 90 100 110 120
GIEVQVAGRI MTRRAMGKAT FITIQDMSGK IQLYVARDNL PEGVYKDDVG TWDLGDIVGI
130 140 150 160 170 180
KGTLFKTKTD ELTVKTTEVQ LLTKALRPLP DKFHGLTDQE VRYRQRYLDL ISNEESRRTF
190 200 210 220 230 240
IIRSKVVAGI REYFISKGFM EVETPMLQVI PGGASARPFV THHNALDVDM YLRIAPELYL
250 260 270 280 290 300
KRLVVGGFER VFELNRNFRN EGVSVRHNPE FTMLEYYQAY ADYHDLMDNT EELLRKLAID
310 320 330 340 350 360
ILGTTIVKYG DLEFDFGKPF ERITLHDATI KYGADKGIVK EDLYDFDRAK ATAERLGIEV
370 380 390 400 410 420
QKSWGLGSIV NAIFEEVAEH HLIQPTFLNG SPAEISPLAR RNDENPEVTD RFELFIGGRE
430 440 450 460 470 480
IGNGFSELND AEDQNERFDA QVAAKEAGDD EAMFKDEDFV VALEHGLPPT AGEGLGIDRL
490 500
AMLYANAPSI RDVILFPAMR QK