P43811
Gene name |
spoT (HI_1741) |
Protein name |
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase |
Names |
Penta-phosphate guanosine-3'-pyrophosphohydrolase, (ppGpp)ase |
Species |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
KEGG Pathway |
hin:HI_1741 |
EC number |
3.1.7.2: Diphosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P43811
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P43811-F1 | Predicted | AlphaFoldDB |
No variants for P43811
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P43811 | |||||
No associated diseases with P43811
6 regional properties for P43811
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.7.2 | Diphosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP diphosphokinase activity | Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. |
| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity | Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| guanosine tetraphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. |
| guanosine tetraphosphate metabolic process | The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. |
| response to starvation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIARDAHEGQ | FRSSGEPYIT | HPVAVASIIA | QLHLDHEAVM | AALLHDVIED | TPYTEEQLKE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFGASVAEIV | DGVSKLDKLK | FRTRQEAQVE | NFRKMILAMT | RDIRVVLIKL | ADRTHNMRTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GSLRPDKRRR | IAKETLEIYC | PLAHRLGIEH | IKNELEDLSF | QAMHPHRYEV | LKKLVDVARS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NRQDLIERIS | QEIKVRLENS | GIFARVWGRE | KHLYKIYQKM | RIKDQEFHSI | MDIYAFRVIV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KNVDDCYRVL | GQMHNLYKPR | PGRVKDYIAV | PKANGYQSLQ | TSMIGPKGVP | VEVHIHTEDM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EQVAEMGITA | HWVYKENGKN | DSTTAQIRVQ | RWLQSLVEIQ | QSVGNSFEFI | ENVKSEFFPK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EIYVFTPKGR | IVELPMGATA | VDFAYAVHSD | VGNTCVGVTV | EHKPYPLSKA | LESGQTVNII |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TDPNAHPEVA | WLNFVVTARA | KTRIRHYLKQ | RCEEDAVKLG | EVELNVALQP | HNLGDFSIQQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRTVLDALAL | SSLDELLREI | GLGNQSASMI | AHQFVGVPLE | SANTKNLEFE | SKILTIAPMQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VGKTQFAQCC | HPILGDPIVG | CCTEKNTVVV | HHQHCASLKN | ACRQSLAKWD | NVQSAVNFEA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELQIEILNEQ | NALLSLMTAI | SASESSLQNI | WTEELENNLL | LVILQVCVKD | IKHLANIVHR |
| 670 | |||||
| IKGITGVVNV | KRNINEL |